STRINGSTRING
ABK72575.1 ABK72575.1 ligC2 ligC2 ligC ligC ku ku dnl1 dnl1 ABK73282.1 ABK73282.1 ABK75979.1 ABK75979.1 ABK71591.1 ABK71591.1 ABK73152.1 ABK73152.1 ABK70606.1 ABK70606.1 ABK71317.1 ABK71317.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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Experiments
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[Homology]
Score
ABK72575.1Conserved hypothetical protein. (426 aa)    
Predicted Functional Partners:
ligC2
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway.
  
 0.954
ligC
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. Belongs to the ATP-dependent DNA ligase family.
  
 0.946
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity.
 
  
 0.924
dnl1
DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family.
  
 0.918
ABK73282.1
Cell filamentation protein; Identified by match to protein family HMM PF02661.
   
  
 0.589
ABK75979.1
acyl-CoA synthase; Identified by match to protein family HMM PF00501.
  
    0.584
ABK71591.1
Periplasmic binding protein; Identified by match to protein family HMM PF01497.
  
    0.558
ABK73152.1
Allophanate hydrolase subunit 1; Identified by match to protein family HMM PF02682.
  
    0.521
ABK70606.1
formamidopyrimidine-DNA glycosylase; Identified by match to protein family HMM PF01149; match to protein family HMM PF06831; Belongs to the FPG family.
 
  
 0.520
ABK71317.1
Type I topoisomerase.
 
    0.482
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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