node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70298.1 | ABK75774.1 | MSMEG_0713 | MSMEG_0699 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Conserved hypothetical proline rich protein. | 0.624 |
ABK70298.1 | clpB | MSMEG_0713 | MSMEG_0732 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.789 |
ABK70298.1 | dnaJ | MSMEG_0713 | MSMEG_0711 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.996 |
ABK70298.1 | dnaJ-2 | MSMEG_0713 | MSMEG_4504 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.820 |
ABK70298.1 | dnaK | MSMEG_0713 | MSMEG_0709 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |
ABK70298.1 | groL | MSMEG_0713 | MSMEG_0880 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.474 |
ABK70298.1 | groL-2 | MSMEG_0713 | MSMEG_1583 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.604 |
ABK70298.1 | groS | MSMEG_0713 | MSMEG_1582 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.569 |
ABK70298.1 | grpE | MSMEG_0713 | MSMEG_0710 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.985 |
ABK70298.1 | hrcA | MSMEG_0713 | MSMEG_4505 | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.810 |
ABK75774.1 | ABK70298.1 | MSMEG_0699 | MSMEG_0713 | Conserved hypothetical proline rich protein. | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | 0.624 |
ABK75774.1 | clpB | MSMEG_0699 | MSMEG_0732 | Conserved hypothetical proline rich protein. | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.700 |
ABK75774.1 | dnaJ | MSMEG_0699 | MSMEG_0711 | Conserved hypothetical proline rich protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.892 |
ABK75774.1 | dnaJ-2 | MSMEG_0699 | MSMEG_4504 | Conserved hypothetical proline rich protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.891 |
ABK75774.1 | groL | MSMEG_0699 | MSMEG_0880 | Conserved hypothetical proline rich protein. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.728 |
ABK75774.1 | groL-2 | MSMEG_0699 | MSMEG_1583 | Conserved hypothetical proline rich protein. | Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.728 |
ABK75774.1 | groS | MSMEG_0699 | MSMEG_1582 | Conserved hypothetical proline rich protein. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.792 |
ABK75774.1 | grpE | MSMEG_0699 | MSMEG_0710 | Conserved hypothetical proline rich protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.941 |
ABK75774.1 | hrcA | MSMEG_0699 | MSMEG_4505 | Conserved hypothetical proline rich protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.721 |
clpB | ABK70298.1 | MSMEG_0732 | MSMEG_0713 | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Transcriptional regulator, MerR family protein; Identified by match to protein family HMM PF00376. | 0.789 |