STRINGSTRING
menD menD menC menC menB menB ABK69697.1 ABK69697.1 menB-2 menB-2 ABK74778.1 ABK74778.1 ABK75828.1 ABK75828.1 menA menA menG menG ABK74033.1 ABK74033.1 ABK73246.1 ABK73246.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
Coexpression
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[Homology]
Score
menD2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (547 aa)    
Predicted Functional Partners:
menC
O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
  
 0.986
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
 
  
 0.985
ABK69697.1
Isochorismate synthase DhbC; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543.
 
 0.979
menB-2
Naphthoate synthase; Identified by match to protein family HMM PF00378; Belongs to the enoyl-CoA hydratase/isomerase family.
 
  
 0.954
ABK74778.1
Probable conserved transmembrane protein.
 
    0.908
ABK75828.1
Hydrolase, alpha/beta fold family protein; Identified by match to protein family HMM PF00561.
  
  
 0.887
menA
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
  
 0.857
menG
Menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
  
  
 0.822
ABK74033.1
Isonitrile hydratase, putative; Identified by match to protein family HMM PF01965.
       0.802
ABK73246.1
Transcriptional regulator, AraC family protein; Identified by match to protein family HMM PF00165; match to protein family HMM PF01965.
       0.758
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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