STRINGSTRING
menG menG menA menA ABK70726.1 ABK70726.1 wrbA wrbA ABK75592.1 ABK75592.1 ABK69857.1 ABK69857.1 menD menD ABK72053.1 ABK72053.1 mgtA mgtA menJ menJ menC menC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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menGMenaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (229 aa)    
Predicted Functional Partners:
menA
1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
    
 0.961
ABK70726.1
Ribosyldihydronicotinamide dehydrogenase (quinone); Identified by match to protein family HMM PF02525.
    
 0.903
wrbA
NAD(P)H:quinone oxidoreductase, type IV; Identified by match to protein family HMM PF00258; match to protein family HMM PF03358; match to protein family HMM TIGR01755; Belongs to the WrbA family.
  
 
  0.903
ABK75592.1
NAD(P)H dehydrogenase, quinone family protein; Identified by similarity to SP:P16083; match to protein family HMM PF02525.
    
 0.903
ABK69857.1
Flavodoxin/nitric oxide synthase.
    
  0.901
menD
2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
  
  
 0.822
ABK72053.1
Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family.
 
  
 0.715
mgtA
Glycosyl transferase; Catalyzes the addition of a mannose residue from GDP-D- mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D- mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)- glycerol(ManGlcAGroAc2); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
     
 0.676
menJ
FAD binding domain, putative; Catalyzes the reduction of a single double bond in the isoprenoid tail of menaquinone (MK-9) in M.smegmatis, likely the beta- isoprene unit, forming the predominant form of menaquinone found in mycobacteria, MK-9(II-H2).
  
  
 0.653
menC
O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
     
 0.642
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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