node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70694.1 | ABK70725.1 | MSMEG_4240 | MSMEG_2346 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Phytoene synthase; Identified by match to protein family HMM PF00494. | 0.972 |
ABK70694.1 | ABK72053.1 | MSMEG_4240 | MSMEG_1133 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 0.930 |
ABK70694.1 | eno | MSMEG_4240 | MSMEG_5415 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.594 |
ABK70694.1 | menG | MSMEG_4240 | MSMEG_1115 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.518 |
ABK70694.1 | ndk | MSMEG_4240 | MSMEG_4627 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.554 |
ABK70694.1 | rnj | MSMEG_4240 | MSMEG_2685 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA. | 0.655 |
ABK70694.1 | uppS | MSMEG_4240 | MSMEG_4490 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and heptaprenyl diphosphate are synthesized. It is probably due to the fact that M.smegmatis synthesizes both (2E,6E,10E)- geranylgeranyl diphosphate (EEE-GGPP) and (2E,6E,10Z)-geranylgeranyl diphosphate (EEZ-GGPP). Can als [...] | 0.809 |
ABK70694.1 | uppS-2 | MSMEG_4240 | MSMEG_5256 | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | 0.976 |
ABK70725.1 | ABK70694.1 | MSMEG_2346 | MSMEG_4240 | Phytoene synthase; Identified by match to protein family HMM PF00494. | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 0.972 |
ABK70725.1 | ABK72053.1 | MSMEG_2346 | MSMEG_1133 | Phytoene synthase; Identified by match to protein family HMM PF00494. | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 0.953 |
ABK70725.1 | menG | MSMEG_2346 | MSMEG_1115 | Phytoene synthase; Identified by match to protein family HMM PF00494. | Menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.415 |
ABK70725.1 | uppS-2 | MSMEG_2346 | MSMEG_5256 | Phytoene synthase; Identified by match to protein family HMM PF00494. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. | 0.443 |
ABK72053.1 | ABK70694.1 | MSMEG_1133 | MSMEG_4240 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Polyprenyl synthetase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | 0.930 |
ABK72053.1 | ABK70725.1 | MSMEG_1133 | MSMEG_2346 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Phytoene synthase; Identified by match to protein family HMM PF00494. | 0.953 |
ABK72053.1 | eno | MSMEG_1133 | MSMEG_5415 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.686 |
ABK72053.1 | htpX | MSMEG_1133 | MSMEG_1134 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Putative protease HtpX; Identified by match to protein family HMM PF01435; Belongs to the peptidase M48B family. | 0.717 |
ABK72053.1 | menG | MSMEG_1133 | MSMEG_1115 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.715 |
ABK72053.1 | menJ | MSMEG_1133 | MSMEG_1132 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | FAD binding domain, putative; Catalyzes the reduction of a single double bond in the isoprenoid tail of menaquinone (MK-9) in M.smegmatis, likely the beta- isoprene unit, forming the predominant form of menaquinone found in mycobacteria, MK-9(II-H2). | 0.867 |
ABK72053.1 | ndk | MSMEG_1133 | MSMEG_4627 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.678 |
ABK72053.1 | rnj | MSMEG_1133 | MSMEG_2685 | Bifunctional short chain isoprenyl diphosphate synthase; Identified by match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family. | Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA. | 0.657 |