STRINGSTRING
hutH hutH hutU hutU hutI hutI hutF hutF hisD-2 hisD-2 egtD egtD ABK75573.1 ABK75573.1 gcvP gcvP ABK76233.1 ABK76233.1 ABK76071.1 ABK76071.1 ABK71810.1 ABK71810.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hutHHistidine ammonia-lyase; Identified by similarity to EGAD:14121; match to protein family HMM PF00221; match to protein family HMM TIGR01225. (514 aa)    
Predicted Functional Partners:
hutU
Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
 
 0.999
hutI
Imidazolonepropionase; Identified by similarity to SP:P42084; match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR01224; Belongs to the metallo-dependent hydrolases superfamily. HutI family.
 
  
 0.998
hutF
Formiminoglutamate deiminase; Identified by match to protein family HMM PF01979; match to protein family HMM PF07969; match to protein family HMM TIGR02022.
 
  
 0.938
hisD-2
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 
 0.936
egtD
Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate.
   
 
 0.915
ABK75573.1
N-carbamoyl-L-amino acid hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM TIGR01879.
  
  
 0.808
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.697
ABK76233.1
Amidohydrolase; Identified by match to protein family HMM PF01979; match to protein family HMM PF07969.
  
  
 0.638
ABK76071.1
Amidohydrolase; Identified by match to protein family HMM PF01979; match to protein family HMM PF07969.
  
  
 0.637
ABK71810.1
Organophopsphate acid anhydrase; Identified by match to protein family HMM PF01979.
  
  
 0.636
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.