STRINGSTRING
ABK71231.1 ABK71231.1 rpoB rpoB rbpA rbpA ABK72811.1 ABK72811.1 ABK70004.1 ABK70004.1 ABK72024.1 ABK72024.1 ABK74889.1 ABK74889.1 ABK73791.1 ABK73791.1 aac aac ABK69666.1 ABK69666.1 ABK75324.1 ABK75324.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ABK71231.1Rifampin ADP-ribosyl transferase. (142 aa)    
Predicted Functional Partners:
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription.
      
 0.675
rbpA
Conserved hypothetical protein; Binds to RNA polymerase (RNAP), probably stimulating transcriptions from principal, but not alternative sigma factor promoters (By similarity). Partially restores transcription in the presence of rifampicin (Rif) in vitro; overexpression leads to an increase in the Rif tolerance in vivo, with smaller colonies. Seems to act by removing Rif from its binding site and preventing its further binding. No longer stimulates transcription in Rif-resistant RNA polymerase (with mutations in rpoB).
   
  
 0.612
ABK72811.1
Thiopurine S-methyltransferase (tpmt) superfamily protein; Identified by match to protein family HMM PF05724.
  
  
 0.602
ABK70004.1
Multidrug-efflux transporter protein; Identified by match to protein family HMM PF07690.
  
    0.602
ABK72024.1
Flavin-type hydroxylase; Identified by match to protein family HMM PF01266; match to protein family HMM PF01494.
     
 0.601
ABK74889.1
Permease of the major facilitator superfamily protein; Identified by match to protein family HMM PF00083; match to protein family HMM PF07690.
  
    0.597
ABK73791.1
Oxalate decarboxylase OxdC, putative; Identified by match to protein family HMM PF00190; match to protein family HMM PF07883.
   
  
 0.588
aac
Aminoglycoside 2'-N-acetyltransferase (AAC(2')-Id); Catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides. It confers resistance to aminoglycosides; Belongs to the AAC(2')-I acetyltransferase family.
  
  
 0.541
ABK69666.1
Superfamily protein I DNA or RNA helicase.
  
  
 0.531
ABK75324.1
ABC-type transport system permease protein I; Identified by match to protein family HMM PF02653; Belongs to the binding-protein-dependent transport system permease family.
  
    0.464
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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