Conserved hypothetical protein; Binds to RNA polymerase (RNAP), probably stimulating transcriptions from principal, but not alternative sigma factor promoters (By similarity). Partially restores transcription in the presence of rifampicin (Rif) in vitro; overexpression leads to an increase in the Rif tolerance in vivo, with smaller colonies. Seems to act by removing Rif from its binding site and preventing its further binding. No longer stimulates transcription in Rif-resistant RNA polymerase (with mutations in rpoB).

Thiopurine S-methyltransferase (tpmt) superfamily protein; Identified by match to protein family HMM PF05724.

Aminoglycoside 2'-N-acetyltransferase (AAC(2')-Id); Catalyzes the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides. It confers resistance to aminoglycosides; Belongs to the AAC(2')-I acetyltransferase family.

Permease of the major facilitator superfamily protein; Identified by match to protein family HMM PF00083; match to protein family HMM PF07690.

Multidrug-efflux transporter protein; Identified by match to protein family HMM PF07690.

Superfamily protein I DNA or RNA helicase.

Oxalate decarboxylase OxdC, putative; Identified by match to protein family HMM PF00190; match to protein family HMM PF07883.

ISMsm6, transposase; Identified by similarity to GP:2935133; match to protein family HMM PF01609.

DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription.