node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70355.1 | ABK70886.1 | MSMEG_0806 | MSMEG_0807 | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | 0.904 |
ABK70355.1 | ABK74900.1 | MSMEG_0806 | MSMEG_1241 | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Conserved hypothetical protein. | 0.621 |
ABK70355.1 | atpE | MSMEG_0806 | MSMEG_4941 | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.562 |
ABK70355.1 | glyA | MSMEG_0806 | MSMEG_5249 | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.518 |
ABK70355.1 | gmk | MSMEG_0806 | MSMEG_3051 | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.487 |
ABK70355.1 | groS | MSMEG_0806 | MSMEG_1582 | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.540 |
ABK70355.1 | nuoC | MSMEG_0806 | MSMEG_2061 | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | NADH-quinone oxidoreductase chain c; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. | 0.599 |
ABK70355.1 | saeC | MSMEG_0806 | MSMEG_0046 | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Conserved hypothetical protein; May be involved in assembly of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Involved in DNA conjugation in recipient (MKD8) strain. | 0.703 |
ABK70886.1 | ABK70355.1 | MSMEG_0807 | MSMEG_0806 | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | 0.904 |
ABK70886.1 | ABK74900.1 | MSMEG_0807 | MSMEG_1241 | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Conserved hypothetical protein. | 0.621 |
ABK70886.1 | atpE | MSMEG_0807 | MSMEG_4941 | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.562 |
ABK70886.1 | glyA | MSMEG_0807 | MSMEG_5249 | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.519 |
ABK70886.1 | gmk | MSMEG_0807 | MSMEG_3051 | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.489 |
ABK70886.1 | groS | MSMEG_0807 | MSMEG_1582 | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.540 |
ABK70886.1 | nuoC | MSMEG_0807 | MSMEG_2061 | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | NADH-quinone oxidoreductase chain c; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. | 0.602 |
ABK70886.1 | saeC | MSMEG_0807 | MSMEG_0046 | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | Conserved hypothetical protein; May be involved in assembly of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Involved in DNA conjugation in recipient (MKD8) strain. | 0.703 |
ABK73018.1 | ABK74900.1 | MSMEG_3126 | MSMEG_1241 | SUF system FeS assembly protein, NifU family protein; Identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994. | Conserved hypothetical protein. | 0.705 |
ABK74900.1 | ABK70355.1 | MSMEG_1241 | MSMEG_0806 | Conserved hypothetical protein. | Hydrolase; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | 0.621 |
ABK74900.1 | ABK70886.1 | MSMEG_1241 | MSMEG_0807 | Conserved hypothetical protein. | Leupeptin-inactivating enzyme 1; Identified by match to protein family HMM PF01546; match to protein family HMM PF02225; match to protein family HMM PF04389. | 0.621 |
ABK74900.1 | ABK73018.1 | MSMEG_1241 | MSMEG_3126 | Conserved hypothetical protein. | SUF system FeS assembly protein, NifU family protein; Identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994. | 0.705 |