node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK72011.1 | ABK72212.1 | MSMEG_1254 | MSMEG_1255 | DEAD/DEAH box helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | 0.770 |
ABK72011.1 | ABK74673.1 | MSMEG_1254 | MSMEG_1256 | DEAD/DEAH box helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. | Hypothetical protein; Identified by Glimmer2; putative. | 0.415 |
ABK72212.1 | ABK72011.1 | MSMEG_1255 | MSMEG_1254 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | DEAD/DEAH box helicase; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271. | 0.770 |
ABK72212.1 | ABK74084.1 | MSMEG_1255 | MSMEG_4259 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. | 0.626 |
ABK72212.1 | ABK74673.1 | MSMEG_1255 | MSMEG_1256 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | Hypothetical protein; Identified by Glimmer2; putative. | 0.767 |
ABK72212.1 | ABK75351.1 | MSMEG_1255 | MSMEG_6892 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.581 |
ABK72212.1 | dnaN | MSMEG_1255 | MSMEG_0001 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.712 |
ABK72212.1 | ligA | MSMEG_1255 | MSMEG_2362 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (Probable). Probably the only ligase required for non-homologous end joining (NHEJ) repair of 3-overhangs; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.523 |
ABK72212.1 | polA | MSMEG_1255 | MSMEG_3839 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.573 |
ABK72212.1 | recA | MSMEG_1255 | MSMEG_2723 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | Protein RecA; Required for homologous recombination (HR) and the bypass of mutagenic DNA lesions (double strand breaks, DSB) by the SOS response. Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. Numerous X-ray crystals have been resolved under different conditions which indicate the flexibility of the protein, essential to its function. Gln-196 contributes to this plasticity by acting as a switch residue, which transmits the ef [...] | 0.740 |
ABK72212.1 | topA | MSMEG_1255 | MSMEG_6157 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...] | 0.758 |
ABK72212.1 | uvrB | MSMEG_1255 | MSMEG_3816 | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.707 |
ABK74084.1 | ABK72212.1 | MSMEG_4259 | MSMEG_1255 | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. | UvrD/Rep helicase; Identified by match to protein family HMM PF00580. | 0.626 |
ABK74084.1 | ABK75351.1 | MSMEG_4259 | MSMEG_6892 | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.413 |
ABK74084.1 | dnaN | MSMEG_4259 | MSMEG_0001 | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.624 |
ABK74084.1 | ligA | MSMEG_4259 | MSMEG_2362 | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (Probable). Probably the only ligase required for non-homologous end joining (NHEJ) repair of 3-overhangs; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.662 |
ABK74084.1 | polA | MSMEG_4259 | MSMEG_3839 | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.943 |
ABK74084.1 | recA | MSMEG_4259 | MSMEG_2723 | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. | Protein RecA; Required for homologous recombination (HR) and the bypass of mutagenic DNA lesions (double strand breaks, DSB) by the SOS response. Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. Numerous X-ray crystals have been resolved under different conditions which indicate the flexibility of the protein, essential to its function. Gln-196 contributes to this plasticity by acting as a switch residue, which transmits the ef [...] | 0.586 |
ABK74084.1 | topA | MSMEG_4259 | MSMEG_6157 | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA sup [...] | 0.726 |
ABK74084.1 | uvrB | MSMEG_4259 | MSMEG_3816 | DNA polymerase III, epsilon subunit; Identified by match to protein family HMM PF00929; match to protein family HMM PF01541; match to protein family HMM TIGR00573. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.951 |