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doc doc phd phd vapB vapB ABK72247.1 ABK72247.1 ABK71736.1 ABK71736.1 ABK71227.1 ABK71227.1 ABK74567.1 ABK74567.1 ABK71328.1 ABK71328.1 vapC vapC mazF mazF ABK73370.1 ABK73370.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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docDeath-on-curing protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon overexpression causes bacteriostasis. Its effect is neutralized by coexpression with cognate antitoxin PhD. May bind the 30S ribosomal subunit. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. (130 aa)    
Predicted Functional Partners:
phd
Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the bacteriostatic effect of cognate toxin Doc. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions.
  
  
 0.965
vapB
Probable ribbon-helix-helix transcription factor, family protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon overexpression neutralizes the effect of overexpressed cognate toxin VapC. Overexpression alone prevents cells from entering a nonculturable dormant state, probably as it binds endogenous VapC. The TA system acts as a post-transcriptional regulator of carbon metabolism; in M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic rea [...]
  
  
 0.809
ABK72247.1
Gp36 protein.
   
  
 0.754
ABK71736.1
Conserved hypothetical protein.
 
     0.637
ABK71227.1
Conserved hypothetical protein.
 
    0.630
ABK74567.1
Hypothetical cytosolic protein.
 
    0.627
ABK71328.1
Identified by match to protein family HMM PF02661.
 
   
 0.627
vapC
PIN domain protein; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease, cleavage occurs after the first AU in the consensus sequence AUA(U/A); RNA secondary structure is probably important in substrate choice. Cuts in 5' and 3' UTRs. The TA system acts as a post-transcriptional regulator of carbon metabolism; in M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. When overexpressed inhibits cell growth, [...]
  
  
 0.602
mazF
Transcriptional modulator of MazE; Toxic component of a type II toxin-antitoxin (TA) system. Upon overexpression inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. Probably an endoribonuclease (By similarity). Belongs to the PemK/MazF family.
  
  
 0.602
ABK73370.1
Identified by match to protein family HMM PF01575.
  
  
 0.588
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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