node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK71648.1 | mazG | MSMEG_1446 | MSMEG_5422 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Transcriptional regulator, MazG family protein; Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation- induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'- triphosphate (8-oxo-dGTP). Also involved in the transcriptional activation of RelA in response to oxidative stress. | 0.828 |
ABK71648.1 | rplB | MSMEG_1446 | MSMEG_1439 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 0.489 |
ABK71648.1 | rplC | MSMEG_1446 | MSMEG_1436 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.447 |
ABK71648.1 | rplD | MSMEG_1446 | MSMEG_1437 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Ribosomal protein L4/L1 family protein; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.452 |
ABK71648.1 | rplP | MSMEG_1446 | MSMEG_1443 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.530 |
ABK71648.1 | rplV | MSMEG_1446 | MSMEG_1441 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | 50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). | 0.552 |
ABK71648.1 | rpmC | MSMEG_1446 | MSMEG_1444 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Ribosomal protein L29; Identified by match to protein family HMM PF00831; match to protein family HMM TIGR00012; Belongs to the universal ribosomal protein uL29 family. | 0.531 |
ABK71648.1 | rpsC | MSMEG_1446 | MSMEG_1442 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. | 0.529 |
ABK71648.1 | rpsQ | MSMEG_1446 | MSMEG_1445 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. | 0.529 |
ABK71648.1 | rpsS | MSMEG_1446 | MSMEG_1440 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. | 0.529 |
mazG | ABK71648.1 | MSMEG_5422 | MSMEG_1446 | Transcriptional regulator, MazG family protein; Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation- induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'- triphosphate (8-oxo-dGTP). Also involved in the transcriptional activation of RelA in response to oxidative stress. | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | 0.828 |
rplB | ABK71648.1 | MSMEG_1439 | MSMEG_1446 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | 0.489 |
rplB | rplC | MSMEG_1439 | MSMEG_1436 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.999 |
rplB | rplD | MSMEG_1439 | MSMEG_1437 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Ribosomal protein L4/L1 family protein; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. | 0.999 |
rplB | rplP | MSMEG_1439 | MSMEG_1443 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. | 0.999 |
rplB | rplV | MSMEG_1439 | MSMEG_1441 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). | 0.999 |
rplB | rpmC | MSMEG_1439 | MSMEG_1444 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Ribosomal protein L29; Identified by match to protein family HMM PF00831; match to protein family HMM TIGR00012; Belongs to the universal ribosomal protein uL29 family. | 0.999 |
rplB | rpsC | MSMEG_1439 | MSMEG_1442 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. | 0.999 |
rplB | rpsQ | MSMEG_1439 | MSMEG_1445 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. | 0.999 |
rplB | rpsS | MSMEG_1439 | MSMEG_1440 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. | Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. | 0.999 |