STRINGSTRING
ABK75199.1 ABK75199.1 ABK75130.1 ABK75130.1 egtD egtD ABK71307.1 ABK71307.1 ABK73930.1 ABK73930.1 egtE egtE egtA egtA dinB-2 dinB-2 ABK73717.1 ABK73717.1 egtB egtB ABK73383.1 ABK73383.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
ABK75199.1Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781. (296 aa)    
Predicted Functional Partners:
ABK75130.1
Arylsulfatase; Identified by match to protein family HMM PF00884.
 
   0.954
egtD
Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate.
 
  
 0.927
ABK71307.1
Identified by match to protein family HMM PF00884.
 
   0.902
ABK73930.1
Sulfatase; Identified by match to protein family HMM PF00884.
 
   0.845
egtE
Pyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily.
  
  
 0.808
egtA
Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.
  
  
 0.739
dinB-2
DNA polymerase IV; Identified by match to protein family HMM PF00817.
     
 0.561
ABK73717.1
Hypothetical protein; Identified by Glimmer2; putative.
  
    0.510
egtB
Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family.
  
  
0.507
ABK73383.1
Conserved hypothetical protein; Identified by match to protein family HMM PF06742; match to protein family HMM PF06863.
 
    0.503
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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