node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK69784.1 | ABK70054.1 | MSMEG_1513 | MSMEG_4425 | Conserved hypothetical protein. | Putative oxidoreductase. | 0.566 |
ABK69784.1 | ABK72199.1 | MSMEG_1513 | MSMEG_1515 | Conserved hypothetical protein. | Two-component sensor histidine kinase; Identified by match to protein family HMM PF00027; match to protein family HMM PF02518. | 0.569 |
ABK69784.1 | ABK74515.1 | MSMEG_1513 | MSMEG_1514 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.713 |
ABK69784.1 | ABK74637.1 | MSMEG_1513 | MSMEG_1635 | Conserved hypothetical protein. | Identified by match to protein family HMM PF00881. | 0.632 |
ABK69784.1 | ABK75334.1 | MSMEG_1513 | MSMEG_2027 | Conserved hypothetical protein. | Conserved hypothetical protein TIGR00026; Identified by match to protein family HMM PF04075; match to protein family HMM TIGR00026. | 0.572 |
ABK69784.1 | fbiB | MSMEG_1513 | MSMEG_1829 | Conserved hypothetical protein. | F420-0:gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. Is able to add up to six glutamates to F420-0, producing F420-3 as the major product with lesser amount of F420-4,5,6, consistent with it producing the polyglutamated F420 compounds present in Mycobacterium smegmatis. In the N-terminal section; belong [...] | 0.519 |
ABK69784.1 | fbiD | MSMEG_1513 | MSMEG_2392 | Conserved hypothetical protein. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.417 |
ABK69784.1 | fgd | MSMEG_1513 | MSMEG_0777 | Conserved hypothetical protein. | F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. Cannot use NAD, NADP, FAD or FMN instead of coenzyme F420 as an electron acceptor. Exhibits nearly no activity with D-mannose-6- phosphate or D-fructose-6-phosphate as substrate. Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family. | 0.445 |
ABK69784.1 | rfbB | MSMEG_1513 | MSMEG_1512 | Conserved hypothetical protein. | dTDP-glucose 4,6-dehydratase; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction (By similarity). Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D- N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. | 0.719 |
ABK69784.1 | rmlC | MSMEG_1513 | MSMEG_1510 | Conserved hypothetical protein. | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. | 0.710 |
ABK70054.1 | ABK69784.1 | MSMEG_4425 | MSMEG_1513 | Putative oxidoreductase. | Conserved hypothetical protein. | 0.566 |
ABK70054.1 | ABK74515.1 | MSMEG_4425 | MSMEG_1514 | Putative oxidoreductase. | Conserved hypothetical protein. | 0.599 |
ABK72199.1 | ABK69784.1 | MSMEG_1515 | MSMEG_1513 | Two-component sensor histidine kinase; Identified by match to protein family HMM PF00027; match to protein family HMM PF02518. | Conserved hypothetical protein. | 0.569 |
ABK72199.1 | ABK74515.1 | MSMEG_1515 | MSMEG_1514 | Two-component sensor histidine kinase; Identified by match to protein family HMM PF00027; match to protein family HMM PF02518. | Conserved hypothetical protein. | 0.615 |
ABK72199.1 | rfbB | MSMEG_1515 | MSMEG_1512 | Two-component sensor histidine kinase; Identified by match to protein family HMM PF00027; match to protein family HMM PF02518. | dTDP-glucose 4,6-dehydratase; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction (By similarity). Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D- N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. | 0.462 |
ABK72199.1 | rmlC | MSMEG_1515 | MSMEG_1510 | Two-component sensor histidine kinase; Identified by match to protein family HMM PF00027; match to protein family HMM PF02518. | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. | 0.457 |
ABK74515.1 | ABK69784.1 | MSMEG_1514 | MSMEG_1513 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.713 |
ABK74515.1 | ABK70054.1 | MSMEG_1514 | MSMEG_4425 | Conserved hypothetical protein. | Putative oxidoreductase. | 0.599 |
ABK74515.1 | ABK72199.1 | MSMEG_1514 | MSMEG_1515 | Conserved hypothetical protein. | Two-component sensor histidine kinase; Identified by match to protein family HMM PF00027; match to protein family HMM PF02518. | 0.615 |
ABK74515.1 | ABK74637.1 | MSMEG_1514 | MSMEG_1635 | Conserved hypothetical protein. | Identified by match to protein family HMM PF00881. | 0.633 |