node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK69833.1 | ABK72510.1 | MSMEG_0071 | MSMEG_1637 | Conserved hypothetical protein. | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | 0.757 |
ABK69833.1 | ABK76080.1 | MSMEG_0071 | MSMEG_0068 | Conserved hypothetical protein. | Probable conserved transmembrane protein; Identified by match to protein family HMM PF04600; match to protein family HMM TIGR02958. | 0.779 |
ABK70730.1 | ABK72510.1 | MSMEG_2467 | MSMEG_1637 | Transketolase, central region; Identified by match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM PF02780. | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | 0.817 |
ABK70730.1 | ABK74408.1 | MSMEG_2467 | MSMEG_4711 | Transketolase, central region; Identified by match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM PF02780. | Pyruvate dehydrogenase E1 component subunit beta; Identified by match to protein family HMM PF02779; match to protein family HMM PF02780. | 0.967 |
ABK70730.1 | prs | MSMEG_2467 | MSMEG_5427 | Transketolase, central region; Identified by match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM PF02780. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.981 |
ABK70730.1 | sucA | MSMEG_2467 | MSMEG_5049 | Transketolase, central region; Identified by match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM PF02780. | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | 0.999 |
ABK72510.1 | ABK69833.1 | MSMEG_1637 | MSMEG_0071 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | Conserved hypothetical protein. | 0.757 |
ABK72510.1 | ABK70730.1 | MSMEG_1637 | MSMEG_2467 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | Transketolase, central region; Identified by match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM PF02780. | 0.817 |
ABK72510.1 | ABK73273.1 | MSMEG_1637 | MSMEG_1638 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | Roadblock/LC7 domain protein; Identified by match to protein family HMM PF03259. | 0.985 |
ABK72510.1 | ABK74408.1 | MSMEG_1637 | MSMEG_4711 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | Pyruvate dehydrogenase E1 component subunit beta; Identified by match to protein family HMM PF02779; match to protein family HMM PF02780. | 0.685 |
ABK72510.1 | ABK74788.1 | MSMEG_1637 | MSMEG_1639 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | Conserved hypothetical protein; Identified by match to protein family HMM PF05331. | 0.985 |
ABK72510.1 | ABK75489.1 | MSMEG_1637 | MSMEG_1640 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | Identified by match to protein family HMM PF03029. | 0.980 |
ABK72510.1 | ABK76080.1 | MSMEG_1637 | MSMEG_0068 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | Probable conserved transmembrane protein; Identified by match to protein family HMM PF04600; match to protein family HMM TIGR02958. | 0.689 |
ABK72510.1 | mfpA | MSMEG_1637 | MSMEG_1641 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | Conserved hypothetical protein; When present on multicopy plasmids confers increased resistance to fluoroquinolone antibiotics such as ciprofloxacin and sparfloxacin but not the quinolone nalidixic acid. Forms a structure that exhibits size, shape and electrostatic similarity to B-form DNA; it may bind to DNA gyrase which is postulated to protect it from fluoroquinolones (By similarity). Belongs to the pentapeptide repeat protein family. | 0.911 |
ABK72510.1 | prs | MSMEG_1637 | MSMEG_5427 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.716 |
ABK72510.1 | sucA | MSMEG_1637 | MSMEG_5049 | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | 0.722 |
ABK73273.1 | ABK72510.1 | MSMEG_1638 | MSMEG_1637 | Roadblock/LC7 domain protein; Identified by match to protein family HMM PF03259. | Periplasmic sensor signal transduction histidine kinase; Identified by match to protein family HMM PF00672; match to protein family HMM PF02518. | 0.985 |
ABK73273.1 | ABK74788.1 | MSMEG_1638 | MSMEG_1639 | Roadblock/LC7 domain protein; Identified by match to protein family HMM PF03259. | Conserved hypothetical protein; Identified by match to protein family HMM PF05331. | 0.987 |
ABK73273.1 | ABK75489.1 | MSMEG_1638 | MSMEG_1640 | Roadblock/LC7 domain protein; Identified by match to protein family HMM PF03259. | Identified by match to protein family HMM PF03029. | 0.999 |
ABK73273.1 | mfpA | MSMEG_1638 | MSMEG_1641 | Roadblock/LC7 domain protein; Identified by match to protein family HMM PF03259. | Conserved hypothetical protein; When present on multicopy plasmids confers increased resistance to fluoroquinolone antibiotics such as ciprofloxacin and sparfloxacin but not the quinolone nalidixic acid. Forms a structure that exhibits size, shape and electrostatic similarity to B-form DNA; it may bind to DNA gyrase which is postulated to protect it from fluoroquinolones (By similarity). Belongs to the pentapeptide repeat protein family. | 0.945 |