STRINGSTRING
mtrB mtrB mtrA mtrA lpqB lpqB regX3 regX3 prrA prrA mprA mprA phoP phoP ABK72873.1 ABK72873.1 resD resD ABK73706.1 ABK73706.1 ABK76216.1 ABK76216.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
mtrBSensor histidine kinase MtrB; Member of the two-component regulatory system MtrA/MtrB. Probably functions as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity). MtrB may be active only at septa where it promotes MtrA phosphorylation and MtrA regulon expression, probably playing a role in cell division. (528 aa)    
Predicted Functional Partners:
mtrA
DNA-binding response regulator MtrA; Member of the two-component regulatory system MtrA/MtrB, responding to environmental signals (Probable). Controls expression of a number of genes including dnaA, ripA, fbpB and probably itself. Probably plays a role in cell division.
 
 0.999
lpqB
LpqB protein; May modulate activity of the MtrAB system in controlling homeostasis of the cell wall and cell division. Belongs to the LpqB lipoprotein family.
 
  
 0.991
regX3
DNA-binding response regulator RegX3; Part of the two-component regulatory system SenX3/RegX3. Once phosphorylated by SenX3, activates the expression of several operons/genes involved in phosphate assimilation and metabolism, such as pstSCAB, phnDCE, and phoA.
 
 
 0.924
prrA
DNA-binding response regulator PrrA; Identified by similarity to SP:Q10531; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.907
mprA
DNA-binding response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).
 
 0.905
phoP
DNA-binding response regulator PhoP; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.837
ABK72873.1
Two component response transcriptional regulatory protein prra; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.832
resD
DNA-binding response regulator ResD; Identified by similarity to SP:P35163; match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 0.832
ABK73706.1
DNA-binding response regulator, PhoP family protein; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
 
 
 0.829
ABK76216.1
Conserved hypothetical protein.
 
    0.816
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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