node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70857.1 | ABK71322.1 | MSMEG_2103 | MSMEG_3977 | 5,10-methylenetetrahydromethanopterin reductase. | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | 0.742 |
ABK70857.1 | ABK72224.1 | MSMEG_2103 | MSMEG_2456 | 5,10-methylenetetrahydromethanopterin reductase. | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | 0.930 |
ABK70857.1 | ABK72595.1 | MSMEG_2103 | MSMEG_3445 | 5,10-methylenetetrahydromethanopterin reductase. | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | 0.962 |
ABK70857.1 | ABK73270.1 | MSMEG_2103 | MSMEG_2811 | 5,10-methylenetetrahydromethanopterin reductase. | Hydride transferase 1; Identified by match to protein family HMM PF00296. | 0.721 |
ABK70857.1 | ABK73664.1 | MSMEG_2103 | MSMEG_2516 | 5,10-methylenetetrahydromethanopterin reductase. | Putative oxidoreductase; Identified by match to protein family HMM PF00296. | 0.729 |
ABK70857.1 | ABK75146.1 | MSMEG_2103 | MSMEG_3620 | 5,10-methylenetetrahydromethanopterin reductase. | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | 0.735 |
ABK70857.1 | ABK75450.1 | MSMEG_2103 | MSMEG_2996 | 5,10-methylenetetrahydromethanopterin reductase. | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | 0.718 |
ABK70857.1 | cofD | MSMEG_2103 | MSMEG_1830 | 5,10-methylenetetrahydromethanopterin reductase. | Lppg:fo 2-phospho-l-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.782 |
ABK70857.1 | fbiB | MSMEG_2103 | MSMEG_1829 | 5,10-methylenetetrahydromethanopterin reductase. | F420-0:gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. Is able to add up to six glutamates to F420-0, producing F420-3 as the major product with lesser amount of F420-4,5,6, consistent with it producing the polyglutamated F420 compounds present in Mycobacterium smegmatis. In the N-terminal section; belong [...] | 0.733 |
ABK70857.1 | glyA | MSMEG_2103 | MSMEG_5249 | 5,10-methylenetetrahydromethanopterin reductase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
ABK71322.1 | ABK70857.1 | MSMEG_3977 | MSMEG_2103 | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | 5,10-methylenetetrahydromethanopterin reductase. | 0.742 |
ABK71322.1 | ABK72224.1 | MSMEG_3977 | MSMEG_2456 | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | 0.730 |
ABK71322.1 | ABK72595.1 | MSMEG_3977 | MSMEG_3445 | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | 0.555 |
ABK71322.1 | cofD | MSMEG_3977 | MSMEG_1830 | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | Lppg:fo 2-phospho-l-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.752 |
ABK71322.1 | fbiB | MSMEG_3977 | MSMEG_1829 | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | F420-0:gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. Is able to add up to six glutamates to F420-0, producing F420-3 as the major product with lesser amount of F420-4,5,6, consistent with it producing the polyglutamated F420 compounds present in Mycobacterium smegmatis. In the N-terminal section; belong [...] | 0.746 |
ABK72224.1 | ABK70857.1 | MSMEG_2456 | MSMEG_2103 | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | 5,10-methylenetetrahydromethanopterin reductase. | 0.930 |
ABK72224.1 | ABK71322.1 | MSMEG_2456 | MSMEG_3977 | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | 0.730 |
ABK72224.1 | ABK72595.1 | MSMEG_2456 | MSMEG_3445 | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | 0.924 |
ABK72224.1 | ABK73270.1 | MSMEG_2456 | MSMEG_2811 | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | Hydride transferase 1; Identified by match to protein family HMM PF00296. | 0.708 |
ABK72224.1 | ABK75450.1 | MSMEG_2456 | MSMEG_2996 | 5,10-methylenetetrahydromethanopterin reductase; Identified by match to protein family HMM PF00296. | Conserved hypothetical protein; Identified by match to protein family HMM PF00296. | 0.748 |