STRINGSTRING
ABK70121.1 ABK70121.1 ligC ligC ku ku ligC2 ligC2 ABK71317.1 ABK71317.1 ABK71306.1 ABK71306.1 dnl1 dnl1 ABK72358.1 ABK72358.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ABK70121.1ATP dependent DNA ligase. (321 aa)    
Predicted Functional Partners:
ligC
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. Belongs to the ATP-dependent DNA ligase family.
   
 0.877
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity.
 
  
 0.871
ligC2
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway.
  
 0.782
ABK71317.1
Type I topoisomerase.
 
    0.648
ABK71306.1
Conserved hypothetical protein.
  
    0.511
dnl1
DNA ligase I, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family.
  
 0.507
ABK72358.1
GntR-family protein transcriptional regulator; Identified by match to protein family HMM PF00155; match to protein family HMM PF00392.
  
    0.421
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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