node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK71359.1 | ABK71627.1 | MSMEG_4348 | MSMEG_0482 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | 0.618 |
ABK71359.1 | ABK71806.1 | MSMEG_4348 | MSMEG_1488 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 0.919 |
ABK71359.1 | ABK74373.1 | MSMEG_4348 | MSMEG_4460 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.907 |
ABK71359.1 | ilvB | MSMEG_4348 | MSMEG_2372 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.920 |
ABK71359.1 | ilvC | MSMEG_4348 | MSMEG_2374 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.969 |
ABK71359.1 | ilvD | MSMEG_4348 | MSMEG_0229 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.565 |
ABK71359.1 | ilvD-2 | MSMEG_4348 | MSMEG_1290 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.537 |
ABK71359.1 | ilvN | MSMEG_4348 | MSMEG_2373 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119; Belongs to the acetolactate synthase small subunit family. | 0.989 |
ABK71359.1 | leuB | MSMEG_4348 | MSMEG_2379 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.956 |
ABK71359.1 | leuD | MSMEG_4348 | MSMEG_2388 | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.473 |
ABK71627.1 | ABK71359.1 | MSMEG_0482 | MSMEG_4348 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | Acetolactate synthase large subunit; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 0.618 |
ABK71627.1 | ABK71806.1 | MSMEG_0482 | MSMEG_1488 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | Acetolactate synthase; Identified by match to protein family HMM PF02775; match to protein family HMM PF02776. | 0.828 |
ABK71627.1 | ABK74373.1 | MSMEG_0482 | MSMEG_4460 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | Acetolactate synthase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.803 |
ABK71627.1 | ilvB | MSMEG_0482 | MSMEG_2372 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | Acetolactate synthase, large subunit, biosynthetic type; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.916 |
ABK71627.1 | ilvC | MSMEG_0482 | MSMEG_2374 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.996 |
ABK71627.1 | ilvD | MSMEG_0482 | MSMEG_0229 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.917 |
ABK71627.1 | ilvD-2 | MSMEG_0482 | MSMEG_1290 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.922 |
ABK71627.1 | ilvN | MSMEG_0482 | MSMEG_2373 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | Acetolactate synthase, small subunit; Identified by match to protein family HMM PF01842; match to protein family HMM TIGR00119; Belongs to the acetolactate synthase small subunit family. | 0.917 |
ABK71627.1 | leuB | MSMEG_0482 | MSMEG_2379 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.840 |
ABK71627.1 | leuD | MSMEG_0482 | MSMEG_2388 | Dihydroxy-acid dehydratase; Identified by match to protein family HMM PF00920; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.859 |