node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70572.1 | gpmA | MSMEG_6338 | MSMEG_0935 | Phosphoglycerate mutase family protein, putative; Identified by match to protein family HMM PF00300. | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | 0.922 |
ABK70572.1 | serA | MSMEG_6338 | MSMEG_2378 | Phosphoglycerate mutase family protein, putative; Identified by match to protein family HMM PF00300. | D-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.910 |
ABK71199.1 | serA | MSMEG_6723 | MSMEG_2378 | Conserved hypothetical protein. | D-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.735 |
ABK71532.1 | ABK75112.1 | MSMEG_5457 | MSMEG_6704 | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | 0.961 |
ABK71532.1 | ABK75362.1 | MSMEG_5457 | MSMEG_4957 | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.805 |
ABK71532.1 | serA | MSMEG_5457 | MSMEG_2378 | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | D-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.832 |
ABK74733.1 | serA | MSMEG_0949 | MSMEG_2378 | HAD-superfamily protein subfamily protein IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | D-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.770 |
ABK74733.1 | serC | MSMEG_0949 | MSMEG_5684 | HAD-superfamily protein subfamily protein IB hydrolase, TIGR01490; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01488; match to protein family HMM TIGR01490. | Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.776 |
ABK75112.1 | ABK71532.1 | MSMEG_6704 | MSMEG_5457 | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | 0.961 |
ABK75112.1 | ABK75362.1 | MSMEG_6704 | MSMEG_4957 | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.827 |
ABK75112.1 | serA | MSMEG_6704 | MSMEG_2378 | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | D-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.829 |
ABK75362.1 | ABK71532.1 | MSMEG_4957 | MSMEG_5457 | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | 0.805 |
ABK75362.1 | ABK75112.1 | MSMEG_4957 | MSMEG_6704 | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488. | 0.827 |
ABK75362.1 | leuB | MSMEG_4957 | MSMEG_2379 | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.534 |
ABK75362.1 | serA | MSMEG_4957 | MSMEG_2378 | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | D-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.790 |
ABK75362.1 | serC | MSMEG_4957 | MSMEG_5684 | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.638 |
glyA | gpmA | MSMEG_5249 | MSMEG_0935 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | 0.429 |
glyA | leuB | MSMEG_5249 | MSMEG_2379 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.420 |
glyA | serA | MSMEG_5249 | MSMEG_2378 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | D-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; match to protein family HMM TIGR01327; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.750 |
glyA | serC | MSMEG_5249 | MSMEG_5684 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.782 |