STRINGSTRING
ABK71799.1 ABK71799.1 sucB sucB sucA sucA ABK72864.1 ABK72864.1 lpdA lpdA pta pta ribBA ribBA ABK70270.1 ABK70270.1 ABK74649.1 ABK74649.1 ABK75118.1 ABK75118.1 ABK74760.1 ABK74760.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ABK71799.1Pyruvate dehydrogenase alpha subunit; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (809 aa)    
Predicted Functional Partners:
sucB
2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817; match to protein family HMM TIGR02927.
  
 
 0.826
sucA
2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...]
  
 
 0.804
ABK72864.1
Dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817.
  
 
 0.761
lpdA
Dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350.
  
  
 0.690
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
  
 0.645
ribBA
Riboflavin biosynthesis protein ribAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.635
ABK70270.1
AsnC-family protein transcriptional regulator; Identified by match to protein family HMM PF01037.
  
  
 0.615
ABK74649.1
Hydroxyquinol 1,2-dioxygenase; Identified by match to protein family HMM PF00775; match to protein family HMM PF04444.
  
  
 0.612
ABK75118.1
Hydroxyquinol 1,2-dioxygenase; Identified by match to protein family HMM PF00775; match to protein family HMM PF04444.
  
  
 0.611
ABK74760.1
AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550.
  
  
 0.609
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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