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cobQ cobQ ABK72513.1 ABK72513.1 cobD cobD cobO cobO ABK70641.1 ABK70641.1 cobB cobB cobM cobM cobK cobK cobU cobU cobS cobS cobL cobL
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (496 aa)    
Predicted Functional Partners:
ABK72513.1
Cobalamin biosynthesis protein cobIJ; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01466; match to protein family HMM TIGR01467; Belongs to the precorrin methyltransferase family.
  
 0.996
cobD
Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
 
 0.993
cobO
cob(I)alamin adenosyltransferase; Identified by match to protein family HMM PF02572; match to protein family HMM TIGR00708.
 
  
 0.986
ABK70641.1
precorrin-8X methylmutase; Identified by match to protein family HMM PF02570.
  
 0.979
cobB
Cobyrinic Acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
  
 0.962
cobM
Precorrin-4 C11-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01465; Belongs to the precorrin methyltransferase family.
 
  
 0.959
cobK
Precorrin-6x reductase; Identified by match to protein family HMM PF02571; match to protein family HMM TIGR00715.
 
  
 0.954
cobU
Cobinamide kinase / cobinamide phosphate guanyltransferase; Identified by match to protein family HMM PF02283.
 
  
 0.953
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.949
cobL
precorrin-6Y C5,15-methyltransferase (decarboxylating); Identified by match to protein family HMM PF00590; match to protein family HMM TIGR02467; match to protein family HMM TIGR02469.
 
  
 0.926
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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