ABK74746.1 protein (Mycolicibacterium smegmatis)

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ABK74746.1

Conserved hypothetical protein; Identified by match to protein family HMM PF06224. (398 aa)

Predicted Functional Partners:

folA

0.704

thyA

0.626

dapA

0.607

rnj

0.596

thyX

0.586

ABK69911.1

0.549

soxR

0.411

Your Current Organism:

Mycolicibacterium smegmatis

NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABK69911.1	ABK74746.1	MSMEG_2678	MSMEG_2679	Hypothetical protein; Identified by Glimmer2; putative.	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	0.549
ABK74746.1	ABK69911.1	MSMEG_2679	MSMEG_2678	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	Hypothetical protein; Identified by Glimmer2; putative.	0.549
ABK74746.1	dapA	MSMEG_2679	MSMEG_2684	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	0.607
ABK74746.1	folA	MSMEG_2679	MSMEG_2671	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.704
ABK74746.1	rnj	MSMEG_2679	MSMEG_2685	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA.	0.596
ABK74746.1	soxR	MSMEG_2679	MSMEG_5450	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	Redox-sensitive transcriptional activator SoxR; Identified by similarity to SP:P22538; match to protein family HMM PF00376; match to protein family HMM TIGR01950.	0.411
ABK74746.1	thyA	MSMEG_2679	MSMEG_2670	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.626
ABK74746.1	thyX	MSMEG_2679	MSMEG_2683	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.586
dapA	ABK74746.1	MSMEG_2684	MSMEG_2679	Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	0.607
dapA	rnj	MSMEG_2684	MSMEG_2685	Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA.	0.924
dapA	thyA	MSMEG_2684	MSMEG_2670	Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.507
dapA	thyX	MSMEG_2684	MSMEG_2683	Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.885
folA	ABK74746.1	MSMEG_2671	MSMEG_2679	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	0.704
folA	thyA	MSMEG_2671	MSMEG_2670	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.999
folA	thyX	MSMEG_2671	MSMEG_2683	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.991
rnj	ABK74746.1	MSMEG_2685	MSMEG_2679	Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA.	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	0.596
rnj	dapA	MSMEG_2685	MSMEG_2684	Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA.	Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	0.924
rnj	thyA	MSMEG_2685	MSMEG_2670	Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.418
rnj	thyX	MSMEG_2685	MSMEG_2683	Metallo-beta-lactamase superfamily protein; An RNase that has endonuclease and 5'-3' exonuclease activity. The 5'-exonuclease activity acts on 5'-monophosphate but not 5'-triphosphate ends. Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA. Plays the major role in pre-23S rRNA maturation, and a minor role in processing of pre- 5S and pre-16S rRNA.	Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.	0.893
soxR	ABK74746.1	MSMEG_5450	MSMEG_2679	Redox-sensitive transcriptional activator SoxR; Identified by similarity to SP:P22538; match to protein family HMM PF00376; match to protein family HMM TIGR01950.	Conserved hypothetical protein; Identified by match to protein family HMM PF06224.	0.411