node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70701.1 | ABK72658.1 | MSMEG_2936 | MSMEG_2934 | Identified by match to protein family HMM PF00293. | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). | 0.985 |
ABK70701.1 | ABK75969.1 | MSMEG_2936 | MSMEG_2932 | Identified by match to protein family HMM PF00293. | Identified by match to protein family HMM PF01230. | 0.972 |
ABK70701.1 | pgsA-2 | MSMEG_2936 | MSMEG_2933 | Identified by match to protein family HMM PF00293. | Phosphatidylinositol synthase; Catalyzes the conjugation of the 1'-hydroxyl group of D-myo- inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall. Is essential to the survival of M.smegmatis. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.938 |
ABK70701.1 | pimA | MSMEG_2936 | MSMEG_2935 | Identified by match to protein family HMM PF00293. | Phosphatidylinositol alpha-mannosyltransferase; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). In contrary to PimB, the mannosyltransferase PimA is unable to transfer a mannose residue to the position 6 of the phosphatidyl-myo-inos [...] | 0.992 |
ABK70701.1 | thrS | MSMEG_2936 | MSMEG_2931 | Identified by match to protein family HMM PF00293. | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.933 |
ABK71746.1 | ABK75709.1 | MSMEG_3652 | MSMEG_0860 | CDP-diacylglycerol-glycerol-3-phosphate; Identified by match to protein family HMM PF01066. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.978 |
ABK71746.1 | cdsA | MSMEG_3652 | MSMEG_2543 | CDP-diacylglycerol-glycerol-3-phosphate; Identified by match to protein family HMM PF01066. | Phosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. | 0.933 |
ABK71746.1 | pgsA | MSMEG_3652 | MSMEG_2692 | CDP-diacylglycerol-glycerol-3-phosphate; Identified by match to protein family HMM PF01066. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.933 |
ABK71746.1 | pgsA-2 | MSMEG_3652 | MSMEG_2933 | CDP-diacylglycerol-glycerol-3-phosphate; Identified by match to protein family HMM PF01066. | Phosphatidylinositol synthase; Catalyzes the conjugation of the 1'-hydroxyl group of D-myo- inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall. Is essential to the survival of M.smegmatis. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.976 |
ABK72658.1 | ABK70701.1 | MSMEG_2934 | MSMEG_2936 | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). | Identified by match to protein family HMM PF00293. | 0.985 |
ABK72658.1 | ABK75969.1 | MSMEG_2934 | MSMEG_2932 | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). | Identified by match to protein family HMM PF01230. | 0.985 |
ABK72658.1 | pgsA-2 | MSMEG_2934 | MSMEG_2933 | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). | Phosphatidylinositol synthase; Catalyzes the conjugation of the 1'-hydroxyl group of D-myo- inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall. Is essential to the survival of M.smegmatis. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.990 |
ABK72658.1 | pimA | MSMEG_2934 | MSMEG_2935 | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). | Phosphatidylinositol alpha-mannosyltransferase; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). In contrary to PimB, the mannosyltransferase PimA is unable to transfer a mannose residue to the position 6 of the phosphatidyl-myo-inos [...] | 0.998 |
ABK72658.1 | thrS | MSMEG_2934 | MSMEG_2931 | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.940 |
ABK75709.1 | ABK71746.1 | MSMEG_0860 | MSMEG_3652 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-diacylglycerol-glycerol-3-phosphate; Identified by match to protein family HMM PF01066. | 0.978 |
ABK75709.1 | cdsA | MSMEG_0860 | MSMEG_2543 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidate cytidylyltransferase; Identified by match to protein family HMM PF01148; Belongs to the CDS family. | 0.936 |
ABK75709.1 | pgsA | MSMEG_0860 | MSMEG_2692 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.978 |
ABK75709.1 | pgsA-2 | MSMEG_0860 | MSMEG_2933 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Identified by match to protein family HMM PF01066; match to protein family HMM TIGR00473; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylinositol synthase; Catalyzes the conjugation of the 1'-hydroxyl group of D-myo- inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall. Is essential to the survival of M.smegmatis. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.975 |
ABK75969.1 | ABK70701.1 | MSMEG_2932 | MSMEG_2936 | Identified by match to protein family HMM PF01230. | Identified by match to protein family HMM PF00293. | 0.972 |
ABK75969.1 | ABK72658.1 | MSMEG_2932 | MSMEG_2934 | Identified by match to protein family HMM PF01230. | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). | 0.985 |