node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK69978.1 | ABK70701.1 | MSMEG_2940 | MSMEG_2936 | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | Identified by match to protein family HMM PF00293. | 0.506 |
ABK69978.1 | ABK72658.1 | MSMEG_2940 | MSMEG_2934 | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). | 0.579 |
ABK69978.1 | ABK75969.1 | MSMEG_2940 | MSMEG_2932 | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | Identified by match to protein family HMM PF01230. | 0.598 |
ABK69978.1 | pdxS | MSMEG_2940 | MSMEG_2937 | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.841 |
ABK69978.1 | pdxT | MSMEG_2940 | MSMEG_2939 | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | Glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.842 |
ABK69978.1 | pgsA-2 | MSMEG_2940 | MSMEG_2933 | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | Phosphatidylinositol synthase; Catalyzes the conjugation of the 1'-hydroxyl group of D-myo- inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall. Is essential to the survival of M.smegmatis. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.506 |
ABK69978.1 | pimA | MSMEG_2940 | MSMEG_2935 | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | Phosphatidylinositol alpha-mannosyltransferase; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). In contrary to PimB, the mannosyltransferase PimA is unable to transfer a mannose residue to the position 6 of the phosphatidyl-myo-inos [...] | 0.523 |
ABK69978.1 | tesB | MSMEG_2940 | MSMEG_2938 | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | acyl-CoA thioesterase II; Identified by match to protein family HMM PF02551; match to protein family HMM TIGR00189. | 0.750 |
ABK69978.1 | thrS | MSMEG_2940 | MSMEG_2931 | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.648 |
ABK70701.1 | ABK69978.1 | MSMEG_2936 | MSMEG_2940 | Identified by match to protein family HMM PF00293. | Conserved hypothetical protein; Identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033. | 0.506 |
ABK70701.1 | ABK71421.1 | MSMEG_2936 | MSMEG_1331 | Identified by match to protein family HMM PF00293. | enoyl-CoA hydratase; Identified by match to protein family HMM PF00378. | 0.439 |
ABK70701.1 | ABK72658.1 | MSMEG_2936 | MSMEG_2934 | Identified by match to protein family HMM PF00293. | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). | 0.985 |
ABK70701.1 | ABK75969.1 | MSMEG_2936 | MSMEG_2932 | Identified by match to protein family HMM PF00293. | Identified by match to protein family HMM PF01230. | 0.972 |
ABK70701.1 | pdxS | MSMEG_2936 | MSMEG_2937 | Identified by match to protein family HMM PF00293. | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.638 |
ABK70701.1 | pdxT | MSMEG_2936 | MSMEG_2939 | Identified by match to protein family HMM PF00293. | Glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.637 |
ABK70701.1 | pgsA-2 | MSMEG_2936 | MSMEG_2933 | Identified by match to protein family HMM PF00293. | Phosphatidylinositol synthase; Catalyzes the conjugation of the 1'-hydroxyl group of D-myo- inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid for mycobacteria required for formation of their cell wall. Is essential to the survival of M.smegmatis. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.938 |
ABK70701.1 | pimA | MSMEG_2936 | MSMEG_2935 | Identified by match to protein family HMM PF00293. | Phosphatidylinositol alpha-mannosyltransferase; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). In contrary to PimB, the mannosyltransferase PimA is unable to transfer a mannose residue to the position 6 of the phosphatidyl-myo-inos [...] | 0.992 |
ABK70701.1 | tesB | MSMEG_2936 | MSMEG_2938 | Identified by match to protein family HMM PF00293. | acyl-CoA thioesterase II; Identified by match to protein family HMM PF02551; match to protein family HMM TIGR00189. | 0.703 |
ABK70701.1 | thrS | MSMEG_2936 | MSMEG_2931 | Identified by match to protein family HMM PF00293. | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). | 0.933 |
ABK71421.1 | ABK70701.1 | MSMEG_1331 | MSMEG_2936 | enoyl-CoA hydratase; Identified by match to protein family HMM PF00378. | Identified by match to protein family HMM PF00293. | 0.439 |