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aroE aroE aroB aroB aroA aroA aroK-2 aroK-2 aroC aroC mltG mltG aroQ aroQ aroQ-2 aroQ-2 ABK71489.1 ABK71489.1 ABK75112.1 ABK75112.1 ABK71532.1 ABK71532.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
aroEShikimate-5-dehydrogenase; Identified by match to protein family HMM PF01488; match to protein family HMM TIGR01809; Belongs to the shikimate dehydrogenase family. (276 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
  
 0.999
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.997
aroK-2
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 
 0.995
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.978
mltG
Conserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family.
  
    0.958
aroQ
3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
 
 
 0.955
aroQ-2
Dehydroquinase dehydratase, type II; Identified by match to protein family HMM PF01220.
 
 
 0.955
ABK71489.1
Peptidase, A24 (type IV prepilin peptidase) family protein; Identified by match to protein family HMM PF01478.
  
  
 0.932
ABK75112.1
Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488.
  
 
0.932
ABK71532.1
Shikimate 5-dehydrogenase; Identified by match to protein family HMM PF01488.
  
 
0.929
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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