node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK75787.1 | hisB | MSMEG_2083 | MSMEG_3207 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | 0.610 |
ABK75787.1 | hisC | MSMEG_2083 | MSMEG_3206 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.927 |
ABK75787.1 | hisC-2 | MSMEG_2083 | MSMEG_6351 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.914 |
ABK75787.1 | hisD-2 | MSMEG_2083 | MSMEG_3205 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.935 |
ABK75787.1 | hisF | MSMEG_2083 | MSMEG_3211 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.623 |
ABK75787.1 | hisG | MSMEG_2083 | MSMEG_4180 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.573 |
ABK75787.1 | hisH | MSMEG_2083 | MSMEG_3208 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.611 |
ABK75787.1 | hisIE | MSMEG_2083 | MSMEG_3212 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.437 |
ABK75787.1 | priA-2 | MSMEG_2083 | MSMEG_3209 | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | Bifunctional HisA/TrpF protein; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.682 |
hisB | ABK75787.1 | MSMEG_3207 | MSMEG_2083 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | 0.610 |
hisB | hisC | MSMEG_3207 | MSMEG_3206 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisC-2 | MSMEG_3207 | MSMEG_6351 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.997 |
hisB | hisD-2 | MSMEG_3207 | MSMEG_3205 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | MSMEG_3207 | MSMEG_3211 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | MSMEG_3207 | MSMEG_4180 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.997 |
hisB | hisH | MSMEG_3207 | MSMEG_3208 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisIE | MSMEG_3207 | MSMEG_3212 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.998 |
hisB | hutH | MSMEG_3207 | MSMEG_1183 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Histidine ammonia-lyase; Identified by similarity to EGAD:14121; match to protein family HMM PF00221; match to protein family HMM TIGR01225. | 0.518 |
hisB | priA-2 | MSMEG_3207 | MSMEG_3209 | Imidazoleglycerol-phosphate dehydratase; Identified by match to protein family HMM PF00475. | Bifunctional HisA/TrpF protein; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.999 |
hisC | ABK75787.1 | MSMEG_3206 | MSMEG_2083 | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Inositol monophosphatase; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067. | 0.927 |