STRINGSTRING
ABK71254.1 ABK71254.1 ABK69757.1 ABK69757.1 ABK71214.1 ABK71214.1 ABK74994.1 ABK74994.1 ABK74685.1 ABK74685.1 ABK76023.1 ABK76023.1 egtA egtA ABK75623.1 ABK75623.1 ABK73625.1 ABK73625.1 egtB egtB egtE egtE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABK71254.1Conserved hypothetical protein. (168 aa)    
Predicted Functional Partners:
ABK69757.1
Conserved hypothetical protein.
  
    0.791
ABK71214.1
RecB family protein exonuclease.
  
    0.790
ABK74994.1
Dtdp-glucose-46-dehydratase.
  
    0.663
ABK74685.1
Hypothetical protein; Identified by Glimmer2; putative.
  
    0.617
ABK76023.1
tRNA (adenine-N(1)-)-methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
  
    0.572
egtA
Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.
  
  
 0.511
ABK75623.1
Putative HTH-type transcriptional regulator; Identified by match to protein family HMM PF00440.
  
    0.447
ABK73625.1
Conserved hypothetical protein.
  
    0.446
egtB
Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family.
   
  
 0.441
egtE
Pyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily.
   
  
 0.438
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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