node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70985.1 | ABK71527.1 | MSMEG_2280 | MSMEG_4150 | Pyruvate dehydrogenase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.606 |
ABK70985.1 | ABK73595.1 | MSMEG_2280 | MSMEG_5826 | Pyruvate dehydrogenase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Pyruvate decarboxylase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.916 |
ABK70985.1 | ABK75384.1 | MSMEG_2280 | MSMEG_3964 | Pyruvate dehydrogenase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Pyruvate dehydrogenase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.900 |
ABK70985.1 | ABK75596.1 | MSMEG_2280 | MSMEG_5943 | Pyruvate dehydrogenase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Putative peroxisomal multifunctional enzyme type 2; Identified by match to protein family HMM PF01575. | 0.469 |
ABK70985.1 | bphI-2 | MSMEG_2280 | MSMEG_5937 | Pyruvate dehydrogenase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.606 |
ABK70985.1 | ilvC | MSMEG_2280 | MSMEG_2374 | Pyruvate dehydrogenase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.583 |
ABK71527.1 | ABK70985.1 | MSMEG_4150 | MSMEG_2280 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Pyruvate dehydrogenase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.606 |
ABK71527.1 | ABK71830.1 | MSMEG_4150 | MSMEG_5940 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 2-keto-4-pentenoate hydratase; Identified by match to protein family HMM PF01689. | 0.989 |
ABK71527.1 | ABK73595.1 | MSMEG_4150 | MSMEG_5826 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Pyruvate decarboxylase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.608 |
ABK71527.1 | ABK74305.1 | MSMEG_4150 | MSMEG_6037 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase; Identified by match to protein family HMM PF00561. | 0.660 |
ABK71527.1 | ABK75382.1 | MSMEG_4150 | MSMEG_4149 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.999 |
ABK71527.1 | ABK75384.1 | MSMEG_4150 | MSMEG_3964 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Pyruvate dehydrogenase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family. | 0.606 |
ABK71527.1 | ABK75596.1 | MSMEG_4150 | MSMEG_5943 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Putative peroxisomal multifunctional enzyme type 2; Identified by match to protein family HMM PF01575. | 0.647 |
ABK71527.1 | bphI-2 | MSMEG_4150 | MSMEG_5937 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.906 |
ABK71527.1 | ilvC | MSMEG_4150 | MSMEG_2374 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.656 |
ABK71527.1 | mhpF | MSMEG_4150 | MSMEG_5939 | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.998 |
ABK71830.1 | ABK71527.1 | MSMEG_5940 | MSMEG_4150 | 2-keto-4-pentenoate hydratase; Identified by match to protein family HMM PF01689. | 4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.989 |
ABK71830.1 | ABK74305.1 | MSMEG_5940 | MSMEG_6037 | 2-keto-4-pentenoate hydratase; Identified by match to protein family HMM PF01689. | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase; Identified by match to protein family HMM PF00561. | 0.649 |
ABK71830.1 | ABK75382.1 | MSMEG_5940 | MSMEG_4149 | 2-keto-4-pentenoate hydratase; Identified by match to protein family HMM PF01689. | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.945 |
ABK71830.1 | ABK75596.1 | MSMEG_5940 | MSMEG_5943 | 2-keto-4-pentenoate hydratase; Identified by match to protein family HMM PF01689. | Putative peroxisomal multifunctional enzyme type 2; Identified by match to protein family HMM PF01575. | 0.643 |