node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK69767.1 | ABK73212.1 | MSMEG_5265 | MSMEG_2394 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | 0.921 |
ABK69767.1 | ABK73488.1 | MSMEG_5265 | MSMEG_6664 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Methylenetetrahydrofolate reductase family protein, putative; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.713 |
ABK69767.1 | ABK75362.1 | MSMEG_5265 | MSMEG_4957 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.937 |
ABK69767.1 | metE | MSMEG_5265 | MSMEG_6638 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.970 |
ABK69767.1 | metH | MSMEG_5265 | MSMEG_4185 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.975 |
ABK69767.1 | metK | MSMEG_5265 | MSMEG_3055 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.640 |
ABK69767.1 | metZ | MSMEG_5265 | MSMEG_0769 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.919 |
ABK72513.1 | metH | MSMEG_3873 | MSMEG_4185 | Cobalamin biosynthesis protein cobIJ; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01466; match to protein family HMM TIGR01467; Belongs to the precorrin methyltransferase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.958 |
ABK73212.1 | ABK69767.1 | MSMEG_2394 | MSMEG_5265 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | 0.921 |
ABK73212.1 | ABK73488.1 | MSMEG_2394 | MSMEG_6664 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | Methylenetetrahydrofolate reductase family protein, putative; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.712 |
ABK73212.1 | ABK75362.1 | MSMEG_2394 | MSMEG_4957 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.892 |
ABK73212.1 | metE | MSMEG_2394 | MSMEG_6638 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.959 |
ABK73212.1 | metH | MSMEG_2394 | MSMEG_4185 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.973 |
ABK73212.1 | metK | MSMEG_2394 | MSMEG_3055 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.498 |
ABK73212.1 | metZ | MSMEG_2394 | MSMEG_0769 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.855 |
ABK73488.1 | ABK69767.1 | MSMEG_6664 | MSMEG_5265 | Methylenetetrahydrofolate reductase family protein, putative; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | 0.713 |
ABK73488.1 | ABK73212.1 | MSMEG_6664 | MSMEG_2394 | Methylenetetrahydrofolate reductase family protein, putative; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | 0.712 |
ABK73488.1 | ABK75362.1 | MSMEG_6664 | MSMEG_4957 | Methylenetetrahydrofolate reductase family protein, putative; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.600 |
ABK73488.1 | gcvT | MSMEG_6664 | MSMEG_4278 | Methylenetetrahydrofolate reductase family protein, putative; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.935 |
ABK73488.1 | glyA | MSMEG_6664 | MSMEG_5249 | Methylenetetrahydrofolate reductase family protein, putative; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.953 |