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trpD trpD ABK69759.1 ABK69759.1 trpE trpE trpA trpA trpB trpB trpC trpC ABK75414.1 ABK75414.1 pabB pabB priA-2 priA-2 ABK72037.1 ABK72037.1 ABK69740.1 ABK69740.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (364 aa)    
Predicted Functional Partners:
ABK69759.1
Anthranilate synthase component 2; Identified by match to protein family HMM PF00117; match to protein family HMM TIGR00566.
 
 0.999
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
 0.999
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.997
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.995
trpC
Indole-3-glycerol phosphate synthase; Identified by match to protein family HMM PF00218; Belongs to the TrpC family.
 
  
 0.992
ABK75414.1
Anthranilate synthase component I; Identified by match to protein family HMM PF00425.
 
 
 0.987
pabB
Para-aminobenzoate synthase, component I; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553.
 
 
 0.976
priA-2
Bifunctional HisA/TrpF protein; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family.
    
 0.945
ABK72037.1
Conserved hypothetical protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
   
 0.846
ABK69740.1
Cytochrome c oxidase subunit 3; Identified by match to protein family HMM PF00510.
  
  
 0.846
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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