STRINGSTRING
ABK75909.1 ABK75909.1 cobU cobU cobT cobT cobS cobS ABK73069.1 ABK73069.1 rbpA rbpA ABK72219.1 ABK72219.1 ABK72160.1 ABK72160.1 ABK72472.1 ABK72472.1 ABK74795.1 ABK74795.1 ABK76142.1 ABK76142.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ABK75909.1Integral membrane protein. (228 aa)    
Predicted Functional Partners:
cobU
Cobinamide kinase / cobinamide phosphate guanyltransferase; Identified by match to protein family HMM PF02283.
  
    0.845
cobT
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
  
    0.844
cobS
Cobalamin 5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
  
    0.822
ABK73069.1
Integral membrane protein.
 
     0.766
rbpA
Conserved hypothetical protein; Binds to RNA polymerase (RNAP), probably stimulating transcriptions from principal, but not alternative sigma factor promoters (By similarity). Partially restores transcription in the presence of rifampicin (Rif) in vitro; overexpression leads to an increase in the Rif tolerance in vivo, with smaller colonies. Seems to act by removing Rif from its binding site and preventing its further binding. No longer stimulates transcription in Rif-resistant RNA polymerase (with mutations in rpoB).
  
     0.764
ABK72219.1
Conserved hypothetical protein.
  
     0.748
ABK72160.1
Conserved hypothetical protein.
  
     0.735
ABK72472.1
DNA polymerase III, delta subunit; Identified by match to protein family HMM PF06144.
  
     0.735
ABK74795.1
Transcriptional regulator, MerR family protein.
  
     0.728
ABK76142.1
Possible conserved transmembrane protein.
  
     0.719
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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