STRINGSTRING
ABK72969.1 ABK72969.1 ABK70911.1 ABK70911.1 ABK73832.1 ABK73832.1 panB panB ABK73866.1 ABK73866.1 glnE glnE glnA-3 glnA-3 ABK73632.1 ABK73632.1 ABK69842.1 ABK69842.1 pks pks ABK71619.1 ABK71619.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ABK72969.1Protease; Identified by match to protein family HMM PF00561. (510 aa)    
Predicted Functional Partners:
ABK70911.1
Acyltransferase, ws/dgat/mgat subfamily protein; Identified by match to protein family HMM PF03007; match to protein family HMM TIGR02946; Belongs to the long-chain O-acyltransferase family.
       0.714
ABK73832.1
Conserved hypothetical protein.
  
     0.678
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
 
  
 0.600
ABK73866.1
Hydrolase, alpha/beta fold family protein; Identified by match to protein family HMM PF00561.
 
   
0.527
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
  
 0.526
glnA-3
Glutamine synthetase, type I; Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback- inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation [...]
  
  
 0.506
ABK73632.1
Conserved hypothetical protein.
      
 0.504
ABK69842.1
Alpha/beta hydrolase; Identified by match to protein family HMM PF00561.
  
 0.495
pks
Type I modular polyketide synthase; Identified by match to protein family HMM PF00106; match to protein family HMM PF00107; match to protein family HMM PF00109; match to protein family HMM PF00550; match to protein family HMM PF00698; match to protein family HMM PF01370; match to protein family HMM PF02801.
  
 
 0.494
ABK71619.1
Serine protease; Identified by match to protein family HMM PF00089; match to protein family HMM PF02674.
  
 0.472
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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