STRINGSTRING
ABK73676.1 ABK73676.1 ABK75863.1 ABK75863.1 ABK74104.1 ABK74104.1 ABK73778.1 ABK73778.1 ABK72219.1 ABK72219.1 ABK76099.1 ABK76099.1 rbpA rbpA dop dop ABK75622.1 ABK75622.1 ABK72979.1 ABK72979.1 pafA pafA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABK73676.1Conserved hypothetical protein. (145 aa)    
Predicted Functional Partners:
ABK75863.1
Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Identified by match to protein family HMM PF00578.
  
  
 0.936
ABK74104.1
Conserved hypothetical protein.
  
  
 0.898
ABK73778.1
Conserved hypothetical protein.
  
    0.766
ABK72219.1
Conserved hypothetical protein.
  
    0.762
ABK76099.1
Acetyltransferase; Identified by match to protein family HMM PF00583.
  
    0.744
rbpA
Conserved hypothetical protein; Binds to RNA polymerase (RNAP), probably stimulating transcriptions from principal, but not alternative sigma factor promoters (By similarity). Partially restores transcription in the presence of rifampicin (Rif) in vitro; overexpression leads to an increase in the Rif tolerance in vivo, with smaller colonies. Seems to act by removing Rif from its binding site and preventing its further binding. No longer stimulates transcription in Rif-resistant RNA polymerase (with mutations in rpoB).
  
    0.721
dop
Proteasome component; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Probably also displays depupylase (DPUP) activity, removing conjugated Pup from target proteins; thus may be involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins. Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.
  
    0.714
ABK75622.1
Conserved hypothetical protein.
  
    0.709
ABK72979.1
Identified by match to protein family HMM PF01022.
  
    0.688
pafA
Proteasome component; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction likely involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine. Belongs to the Pup ligase/Pup deamidase family. Pup- conjugating enzyme subfamily.
  
    0.681
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.