STRINGSTRING
mazE mazE mazF mazF vapB vapB ABK73716.1 ABK73716.1 modA modA deaD deaD modB modB ABK72012.1 ABK72012.1 vapC vapC lon lon ABK72904.1 ABK72904.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mazEConserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of cognate toxin MazF. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. (69 aa)    
Predicted Functional Partners:
mazF
Transcriptional modulator of MazE; Toxic component of a type II toxin-antitoxin (TA) system. Upon overexpression inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE. In M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. Probably an endoribonuclease (By similarity). Belongs to the PemK/MazF family.
 
  
 0.991
vapB
Probable ribbon-helix-helix transcription factor, family protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon overexpression neutralizes the effect of overexpressed cognate toxin VapC. Overexpression alone prevents cells from entering a nonculturable dormant state, probably as it binds endogenous VapC. The TA system acts as a post-transcriptional regulator of carbon metabolism; in M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic rea [...]
  
  
 0.884
ABK73716.1
Identified by match to protein family HMM PF05534.
   
  
 0.596
modA
Molybdate ABC transporter, periplasmic molybdate-binding protein; Identified by match to protein family HMM PF01547; match to protein family HMM TIGR01256.
   
  
 0.593
deaD
ATP-dependent rna helicase, dead/deah box family protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.
   
  
 0.592
modB
Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
   
  
 0.520
ABK72012.1
Ankyrin-repeat containing protein.
   
  
 0.518
vapC
PIN domain protein; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease, cleavage occurs after the first AU in the consensus sequence AUA(U/A); RNA secondary structure is probably important in substrate choice. Cuts in 5' and 3' UTRs. The TA system acts as a post-transcriptional regulator of carbon metabolism; in M.smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions. When overexpressed inhibits cell growth, [...]
  
  
 0.471
lon
ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
   
  
 0.451
ABK72904.1
Conserved hypothetical protein.
  
   
 0.429
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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