STRINGSTRING
ABK72356.1 ABK72356.1 ABK70840.1 ABK70840.1 ABK75232.1 ABK75232.1 ABK74213.1 ABK74213.1 lfrA lfrA sucA sucA
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second shell of interactors
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ABK72356.1Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. (417 aa)    
Predicted Functional Partners:
ABK70840.1
Drug transporter; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; Belongs to the major facilitator superfamily.
 
    
0.593
ABK75232.1
Conserved hypothetical protein.
  
    0.531
ABK74213.1
Transmembrane efflux pump; Identified by match to protein family HMM PF07690.
  
     0.410
lfrA
Proton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force.
 
   
 0.409
sucA
2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...]
  
  
 0.401
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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