node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70840.1 | ABK72356.1 | MSMEG_5046 | MSMEG_5047 | Drug transporter; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; Belongs to the major facilitator superfamily. | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | 0.593 |
ABK70840.1 | ABK75232.1 | MSMEG_5046 | MSMEG_5048 | Drug transporter; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; Belongs to the major facilitator superfamily. | Conserved hypothetical protein. | 0.690 |
ABK70840.1 | sucA | MSMEG_5046 | MSMEG_5049 | Drug transporter; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; Belongs to the major facilitator superfamily. | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | 0.425 |
ABK72356.1 | ABK70840.1 | MSMEG_5047 | MSMEG_5046 | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | Drug transporter; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; Belongs to the major facilitator superfamily. | 0.593 |
ABK72356.1 | ABK74213.1 | MSMEG_5047 | MSMEG_4427 | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | Transmembrane efflux pump; Identified by match to protein family HMM PF07690. | 0.410 |
ABK72356.1 | ABK75232.1 | MSMEG_5047 | MSMEG_5048 | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | Conserved hypothetical protein. | 0.531 |
ABK72356.1 | lfrA | MSMEG_5047 | MSMEG_6225 | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | Proton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force. | 0.409 |
ABK72356.1 | sucA | MSMEG_5047 | MSMEG_5049 | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | 0.401 |
ABK74213.1 | ABK72356.1 | MSMEG_4427 | MSMEG_5047 | Transmembrane efflux pump; Identified by match to protein family HMM PF07690. | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | 0.410 |
ABK75232.1 | ABK70840.1 | MSMEG_5048 | MSMEG_5046 | Conserved hypothetical protein. | Drug transporter; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; Belongs to the major facilitator superfamily. | 0.690 |
ABK75232.1 | ABK72356.1 | MSMEG_5048 | MSMEG_5047 | Conserved hypothetical protein. | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | 0.531 |
ABK75232.1 | sucA | MSMEG_5048 | MSMEG_5049 | Conserved hypothetical protein. | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | 0.631 |
lfrA | ABK72356.1 | MSMEG_6225 | MSMEG_5047 | Proton antiporter efflux pump; Energy-dependent efflux pump that contributes to drug resistance. Catalyzes the efflux of norfloxacin and several related fluoroquinolones (FQ). Contributes significantly to the intrinsic MICs for ethidium bromide and acriflavine. Overexpression confers low-level resistance to hydrophilic FQ such as ciprofloxacin, ofloxacin and levofloxacin, and to ethidium bromide, acridine, acriflavine, rhodamine 123 and some quaternary ammonium compounds. May contribute to resistance to certain beta-lactams. Probably uses the proton motive force. | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | 0.409 |
sucA | ABK70840.1 | MSMEG_5049 | MSMEG_5046 | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | Drug transporter; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00711; Belongs to the major facilitator superfamily. | 0.425 |
sucA | ABK72356.1 | MSMEG_5049 | MSMEG_5047 | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | Drug resistance transporter Bcr/CflA subfamily protein; Identified by match to protein family HMM PF07690; match to protein family HMM TIGR00710. | 0.401 |
sucA | ABK75232.1 | MSMEG_5049 | MSMEG_5048 | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | Conserved hypothetical protein. | 0.631 |