STRINGSTRING
ABK71314.1 ABK71314.1 esxA esxA clpC1 clpC1 clpB clpB ABK73065.1 ABK73065.1 ABK75360.1 ABK75360.1 dnaK dnaK ABK75863.1 ABK75863.1 ABK70160.1 ABK70160.1 ABK72999.1 ABK72999.1 ABK70019.1 ABK70019.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Experiments
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Textmining
[Homology]
Score
ABK71314.1Spore protein; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. (152 aa)    
Predicted Functional Partners:
esxA
Early secretory antigenic target, 6 kDa; An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH. Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart.
   
  
 0.768
clpC1
Negative regulator of genetic competence ClpC/mecB; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2 (Probable); Belongs to the ClpA/ClpB family. ClpC subfamily.
  
 
 0.699
clpB
Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.684
ABK73065.1
Immunogenic protein MPB64/MPT64.
   
 
 0.656
ABK75360.1
Immunogenic protein MPB64/MPT64.
   
 
 0.656
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.649
ABK75863.1
Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Identified by match to protein family HMM PF00578.
  
  
 0.644
ABK70160.1
Clp amino terminal domain protein; Identified by match to protein family HMM PF02861.
  
 
 0.641
ABK72999.1
Putative Clp protease subunit; Identified by match to protein family HMM PF02861.
  
 
 0.641
ABK70019.1
Peptidase M22, glycoprotease; Identified by match to protein family HMM PF00814.
     
 0.628
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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