node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK69737.1 | ABK75407.1 | MSMEG_1112 | MSMEG_5676 | Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. | Citrate synthase; Identified by match to protein family HMM PF00285; Belongs to the citrate synthase family. | 0.987 |
ABK69737.1 | acnA | MSMEG_1112 | MSMEG_3143 | Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. | Aconitate hydratase 1; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein. Could catalyze the hydration of 2-methyl-cis- aconitate to yield (2R,3S)-2-methylisocitrate. | 0.901 |
ABK69737.1 | glcB | MSMEG_1112 | MSMEG_3640 | Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.415 |
ABK69737.1 | gltA | MSMEG_1112 | MSMEG_5672 | Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. | Citrate synthase I; Identified by similarity to SP:P42457; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family. | 0.988 |
ABK69737.1 | sucA | MSMEG_1112 | MSMEG_5049 | Aconitate hydratase, putative; Identified by match to protein family HMM PF00330; match to protein family HMM PF00694; match to protein family HMM TIGR01342. | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | 0.731 |
ABK70948.1 | ABK72864.1 | MSMEG_0718 | MSMEG_4710 | acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. | Dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817. | 0.921 |
ABK70948.1 | ABK75407.1 | MSMEG_0718 | MSMEG_5676 | acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. | Citrate synthase; Identified by match to protein family HMM PF00285; Belongs to the citrate synthase family. | 0.952 |
ABK70948.1 | acsA | MSMEG_0718 | MSMEG_6179 | acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.932 |
ABK70948.1 | glcB | MSMEG_0718 | MSMEG_3640 | acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.952 |
ABK70948.1 | gltA | MSMEG_0718 | MSMEG_5672 | acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. | Citrate synthase I; Identified by similarity to SP:P42457; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family. | 0.954 |
ABK70948.1 | pyc | MSMEG_0718 | MSMEG_2412 | acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.834 |
ABK70948.1 | pyc-2 | MSMEG_0718 | MSMEG_6648 | acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.834 |
ABK70948.1 | sucA | MSMEG_0718 | MSMEG_5049 | acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. | 2-oxoglutarate dehydrogenase, E1 component; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxoadipate [...] | 0.406 |
ABK72864.1 | ABK70948.1 | MSMEG_4710 | MSMEG_0718 | Dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817. | acetyl-CoA synthetase; Identified by match to protein family HMM PF00501. | 0.921 |
ABK72864.1 | ABK75407.1 | MSMEG_4710 | MSMEG_5676 | Dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817. | Citrate synthase; Identified by match to protein family HMM PF00285; Belongs to the citrate synthase family. | 0.963 |
ABK72864.1 | acnA | MSMEG_4710 | MSMEG_3143 | Dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817. | Aconitate hydratase 1; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein. Could catalyze the hydration of 2-methyl-cis- aconitate to yield (2R,3S)-2-methylisocitrate. | 0.494 |
ABK72864.1 | acsA | MSMEG_4710 | MSMEG_6179 | Dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.915 |
ABK72864.1 | glcB | MSMEG_4710 | MSMEG_3640 | Dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.915 |
ABK72864.1 | gltA | MSMEG_4710 | MSMEG_5672 | Dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817. | Citrate synthase I; Identified by similarity to SP:P42457; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family. | 0.967 |
ABK72864.1 | pyc | MSMEG_4710 | MSMEG_2412 | Dihydrolipoamide acetyltransferase; Identified by match to protein family HMM PF00198; match to protein family HMM PF00364; match to protein family HMM PF02817. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.833 |