node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70217.1 | ABK74492.1 | MSMEG_2299 | MSMEG_5786 | Ribonucleoside-diphosphate reductase, alpha subunit; Identified by match to protein family HMM PF00317; match to protein family HMM PF02867; match to protein family HMM TIGR02506. | Thiredoxin; Identified by match to protein family HMM PF00085. | 0.757 |
ABK70706.1 | ABK74492.1 | MSMEG_5785 | MSMEG_5786 | Probable exported protein. | Thiredoxin; Identified by match to protein family HMM PF00085. | 0.939 |
ABK70706.1 | ABK74988.1 | MSMEG_5785 | MSMEG_5784 | Probable exported protein. | Transcriptional regulatory protein; Identified by match to protein family HMM PF00486. | 0.642 |
ABK73669.1 | ABK74492.1 | MSMEG_4891 | MSMEG_5786 | Alkylhydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in det [...] | Thiredoxin; Identified by match to protein family HMM PF00085. | 0.920 |
ABK73669.1 | ABK75315.1 | MSMEG_4891 | MSMEG_1735 | Alkylhydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in det [...] | Dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992. | 0.474 |
ABK73669.1 | rpoB | MSMEG_4891 | MSMEG_1367 | Alkylhydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in det [...] | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription. | 0.807 |
ABK73669.1 | sodC | MSMEG_4891 | MSMEG_0835 | Alkylhydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in det [...] | Copper/zinc superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. | 0.873 |
ABK74492.1 | ABK70217.1 | MSMEG_5786 | MSMEG_2299 | Thiredoxin; Identified by match to protein family HMM PF00085. | Ribonucleoside-diphosphate reductase, alpha subunit; Identified by match to protein family HMM PF00317; match to protein family HMM PF02867; match to protein family HMM TIGR02506. | 0.757 |
ABK74492.1 | ABK70706.1 | MSMEG_5786 | MSMEG_5785 | Thiredoxin; Identified by match to protein family HMM PF00085. | Probable exported protein. | 0.939 |
ABK74492.1 | ABK73669.1 | MSMEG_5786 | MSMEG_4891 | Thiredoxin; Identified by match to protein family HMM PF00085. | Alkylhydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in det [...] | 0.920 |
ABK74492.1 | ABK74988.1 | MSMEG_5786 | MSMEG_5784 | Thiredoxin; Identified by match to protein family HMM PF00085. | Transcriptional regulatory protein; Identified by match to protein family HMM PF00486. | 0.839 |
ABK74492.1 | ABK75315.1 | MSMEG_5786 | MSMEG_1735 | Thiredoxin; Identified by match to protein family HMM PF00085. | Dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992. | 0.745 |
ABK74492.1 | msrA | MSMEG_5786 | MSMEG_4417 | Thiredoxin; Identified by match to protein family HMM PF00085. | methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.868 |
ABK74492.1 | msrA-2 | MSMEG_5786 | MSMEG_6477 | Thiredoxin; Identified by match to protein family HMM PF00085. | methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.870 |
ABK74492.1 | nrdE1 | MSMEG_5786 | MSMEG_1019 | Thiredoxin; Identified by match to protein family HMM PF00085. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity); Belongs to the ribonucleoside diphosphate reductase large chain family. | 0.757 |
ABK74492.1 | rpoB | MSMEG_5786 | MSMEG_1367 | Thiredoxin; Identified by match to protein family HMM PF00085. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription. | 0.794 |
ABK74492.1 | sodC | MSMEG_5786 | MSMEG_0835 | Thiredoxin; Identified by match to protein family HMM PF00085. | Copper/zinc superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. | 0.753 |
ABK74988.1 | ABK70706.1 | MSMEG_5784 | MSMEG_5785 | Transcriptional regulatory protein; Identified by match to protein family HMM PF00486. | Probable exported protein. | 0.642 |
ABK74988.1 | ABK74492.1 | MSMEG_5784 | MSMEG_5786 | Transcriptional regulatory protein; Identified by match to protein family HMM PF00486. | Thiredoxin; Identified by match to protein family HMM PF00085. | 0.839 |
ABK75315.1 | ABK73669.1 | MSMEG_1735 | MSMEG_4891 | Dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992. | Alkylhydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in det [...] | 0.474 |