node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK71619.1 | ABK72436.1 | MSMEG_6183 | MSMEG_6186 | Serine protease; Identified by match to protein family HMM PF00089; match to protein family HMM PF02674. | Conserved hypothetical protein. | 0.891 |
ABK71619.1 | ABK75102.1 | MSMEG_6183 | MSMEG_6185 | Serine protease; Identified by match to protein family HMM PF00089; match to protein family HMM PF02674. | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | 0.897 |
ABK71619.1 | nth | MSMEG_6183 | MSMEG_6187 | Serine protease; Identified by match to protein family HMM PF00089; match to protein family HMM PF02674. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.837 |
ABK72436.1 | ABK71619.1 | MSMEG_6186 | MSMEG_6183 | Conserved hypothetical protein. | Serine protease; Identified by match to protein family HMM PF00089; match to protein family HMM PF02674. | 0.891 |
ABK72436.1 | ABK73669.1 | MSMEG_6186 | MSMEG_4891 | Conserved hypothetical protein. | Alkylhydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in det [...] | 0.919 |
ABK72436.1 | ABK74914.1 | MSMEG_6186 | MSMEG_4268 | Conserved hypothetical protein. | Cytochrome c oxidase subunit 2; Identified by match to protein family HMM PF00116. | 0.791 |
ABK72436.1 | ABK75102.1 | MSMEG_6186 | MSMEG_6185 | Conserved hypothetical protein. | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | 0.892 |
ABK72436.1 | msrA | MSMEG_6186 | MSMEG_4417 | Conserved hypothetical protein. | methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.870 |
ABK72436.1 | msrA-2 | MSMEG_6186 | MSMEG_6477 | Conserved hypothetical protein. | methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.870 |
ABK72436.1 | nrdE1 | MSMEG_6186 | MSMEG_1019 | Conserved hypothetical protein. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity); Belongs to the ribonucleoside diphosphate reductase large chain family. | 0.762 |
ABK72436.1 | nth | MSMEG_6186 | MSMEG_6187 | Conserved hypothetical protein. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.895 |
ABK72436.1 | rpoB | MSMEG_6186 | MSMEG_1367 | Conserved hypothetical protein. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription. | 0.795 |
ABK72436.1 | saeC | MSMEG_6186 | MSMEG_0046 | Conserved hypothetical protein. | Conserved hypothetical protein; May be involved in assembly of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. Involved in DNA conjugation in recipient (MKD8) strain. | 0.758 |
ABK73669.1 | ABK72436.1 | MSMEG_4891 | MSMEG_6186 | Alkylhydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in det [...] | Conserved hypothetical protein. | 0.919 |
ABK73669.1 | rpoB | MSMEG_4891 | MSMEG_1367 | Alkylhydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Together with AhpD, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system. Does not however seem to play a role in det [...] | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit often mutates to generate rifampicin (Rif) resistance. Interaction with RbpA partially restores Rif-inhibited transcription; once the subunit is Rif-resistant however RbpA no longer stimulates transcription. | 0.807 |
ABK74914.1 | ABK72436.1 | MSMEG_4268 | MSMEG_6186 | Cytochrome c oxidase subunit 2; Identified by match to protein family HMM PF00116. | Conserved hypothetical protein. | 0.791 |
ABK75102.1 | ABK71619.1 | MSMEG_6185 | MSMEG_6183 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Serine protease; Identified by match to protein family HMM PF00089; match to protein family HMM PF02674. | 0.897 |
ABK75102.1 | ABK72436.1 | MSMEG_6185 | MSMEG_6186 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Conserved hypothetical protein. | 0.892 |
ABK75102.1 | nth | MSMEG_6185 | MSMEG_6187 | NTP pyrophosphohydrolase; Identified by match to protein family HMM PF00293. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.865 |
msrA | ABK72436.1 | MSMEG_4417 | MSMEG_6186 | methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | Conserved hypothetical protein. | 0.870 |