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egtE egtE egtC egtC egtB egtB egtD egtD egtA egtA ABK73018.1 ABK73018.1 sufD sufD sufC sufC sufB sufB ABK71897.1 ABK71897.1 ABK75199.1 ABK75199.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
egtEPyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. (371 aa)    
Predicted Functional Partners:
egtC
Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
 
 
 0.998
egtB
Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family.
 
  
 0.995
egtD
Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate.
  
  
 0.993
egtA
Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.
 
  
 0.989
ABK73018.1
SUF system FeS assembly protein, NifU family protein; Identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994.
 
 
 0.925
sufD
FeS assembly protein SufD; Identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981.
 
 
 0.895
sufC
FeS assembly ATPase SufC; Identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978.
 
  
 0.881
sufB
FeS assembly protein SufB; Identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980.
 
 
 0.822
ABK71897.1
Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781.
  
  
 0.808
ABK75199.1
Sulfatase-modifying factor 1; Identified by match to protein family HMM PF03781.
  
  
 0.808
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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