STRINGSTRING
ABK75515.1 ABK75515.1 ABK69525.1 ABK69525.1 atpD atpD egtA egtA egtC egtC egtD egtD ABK70779.1 ABK70779.1 egtB egtB egtE egtE ABK74212.1 ABK74212.1 ABK74978.1 ABK74978.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABK75515.1Conserved hypothetical protein. (217 aa)    
Predicted Functional Partners:
ABK69525.1
Conserved hypothetical protein.
  
    0.796
atpD
ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family.
   
  
 0.585
egtA
Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC) (By similarity). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.
  
    0.570
egtC
Conserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
  
    0.564
egtD
Conserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine. Among all the proteinogenic amino acids, only L-histidine is a substrate.
  
    0.561
ABK70779.1
Conserved hypothetical protein; Identified by match to protein family HMM PF02566.
  
    0.559
egtB
Conserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. Cannot use the alternative thiols cysteine, N- acetylcysteine, or glutathione instead of gamma-glutamylcysteine as substrates, and histidine is a poor sulfur acceptor substrate compared to hercynine; Belongs to the EgtB family.
  
    0.558
egtE
Pyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is a secreted antioxidant that protects mycobacterium from oxidative stress. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily.
  
    0.548
ABK74212.1
Fur family protein transcriptional regulator; Identified by match to protein family HMM PF01475; Belongs to the Fur family.
  
    0.470
ABK74978.1
Hypothetical protein; Identified by Glimmer2; putative.
       0.467
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.