node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK70121.1 | ku | MSMEG_2105 | MSMEG_5580 | ATP dependent DNA ligase. | Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity. | 0.871 |
ABK70121.1 | ligC2 | MSMEG_2105 | MSMEG_6304 | ATP dependent DNA ligase. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. | 0.782 |
ABK70876.1 | ku | MSMEG_6343 | MSMEG_5580 | Conserved hypothetical protein; Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040. | Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity. | 0.515 |
ABK70876.1 | ligA | MSMEG_6343 | MSMEG_2362 | Conserved hypothetical protein; Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (Probable). Probably the only ligase required for non-homologous end joining (NHEJ) repair of 3-overhangs; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.416 |
ABK70876.1 | ligC2 | MSMEG_6343 | MSMEG_6304 | Conserved hypothetical protein; Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. | 0.861 |
ABK70876.1 | ligD | MSMEG_6343 | MSMEG_6301 | Conserved hypothetical protein; Identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040. | DNA polymerase LigD, polymerase domain; Identified by match to protein family HMM TIGR02778. | 0.628 |
ABK72031.1 | ABK73081.1 | MSMEG_3883 | MSMEG_5518 | 5'-3' exonuclease; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739. | Antigen 34 kDa. | 0.826 |
ABK72031.1 | dnaN | MSMEG_3883 | MSMEG_0001 | 5'-3' exonuclease; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.960 |
ABK72031.1 | ligA | MSMEG_3883 | MSMEG_2362 | 5'-3' exonuclease; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (Probable). Probably the only ligase required for non-homologous end joining (NHEJ) repair of 3-overhangs; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.407 |
ABK72031.1 | ligC2 | MSMEG_3883 | MSMEG_6304 | 5'-3' exonuclease; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. | 0.863 |
ABK72031.1 | ligD | MSMEG_3883 | MSMEG_6301 | 5'-3' exonuclease; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739. | DNA polymerase LigD, polymerase domain; Identified by match to protein family HMM TIGR02778. | 0.417 |
ABK72031.1 | polA | MSMEG_3883 | MSMEG_3839 | 5'-3' exonuclease; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.787 |
ABK72575.1 | ku | MSMEG_0597 | MSMEG_5580 | Conserved hypothetical protein. | Ku protein; With LigD forms a non-homologous end joining (NHEJ) repair enzyme which repairs blunt-end and 5'-overhang double strand breaks (DSB) with about 50% fidelity, and DSB with non-complementary 3' ends. Plays a partial role in NHEJ on 3'-overhang repair of complementary ends. NHEJ repairs DSB with blunt ends and 5' overhangs with a high level of nucleotide insertion/deletion, without a need for microhomology. This protein but not LigD also suppresses homologous recombination. Overexpression dramatically increases the efficiency of NHEJ with no effect on repair fidelity. | 0.924 |
ABK72575.1 | ligC2 | MSMEG_0597 | MSMEG_6304 | Conserved hypothetical protein. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. | 0.954 |
ABK73081.1 | ABK72031.1 | MSMEG_5518 | MSMEG_3883 | Antigen 34 kDa. | 5'-3' exonuclease; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739. | 0.826 |
ABK73081.1 | dnaN | MSMEG_5518 | MSMEG_0001 | Antigen 34 kDa. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.695 |
ABK73081.1 | ligC2 | MSMEG_5518 | MSMEG_6304 | Antigen 34 kDa. | DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity). Has weak intrinsic nick joining activities and accumulates DNA-adenylate. Acts as a backup for LigD in the Ku-LigD-dependent NHEJ pathway. | 0.731 |
ABK73081.1 | polA | MSMEG_5518 | MSMEG_3839 | Antigen 34 kDa. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.939 |
dnaN | ABK72031.1 | MSMEG_0001 | MSMEG_3883 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 5'-3' exonuclease; Identified by match to protein family HMM PF01367; match to protein family HMM PF02739. | 0.960 |
dnaN | ABK73081.1 | MSMEG_0001 | MSMEG_5518 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Antigen 34 kDa. | 0.695 |