node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK71692.1 | ABK76192.1 | MSMEG_6366 | MSMEG_6369 | O-antigen export system, ATP-binding protein; Identified by match to protein family HMM PF00005. | O-antigen export system, permease protein; Identified by match to protein family HMM PF01061. | 0.999 |
ABK71692.1 | bpa | MSMEG_6366 | MSMEG_6365 | O-antigen export system, ATP-binding protein; Identified by match to protein family HMM PF00005. | Conserved hypothetical protein; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction (By similarity); Belongs to the Bpa family. | 0.966 |
ABK71692.1 | glf | MSMEG_6366 | MSMEG_6404 | O-antigen export system, ATP-binding protein; Identified by match to protein family HMM PF00005. | UDP-galactopyranose mutase; Identified by match to protein family HMM PF03275; match to protein family HMM TIGR00031. | 0.655 |
ABK71692.1 | glfT1 | MSMEG_6366 | MSMEG_6367 | O-antigen export system, ATP-binding protein; Identified by match to protein family HMM PF00005. | Glycosyl transferase, group 2 family protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the transfer of the first two galactofuranosyl (Galf) units from UDP- galactofuranose (UDP-Galf) onto the rhamnosyl-GlcNAc-diphospho- decaprenol (Rha-GlcNAc-PP-C50) acceptor, yielding galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50). Thus, GlfT1 is the initiator of galactan synthesis, while GlfT2 cont [...] | 0.993 |
ABK71692.1 | glfT2 | MSMEG_6366 | MSMEG_6403 | O-antigen export system, ATP-binding protein; Identified by match to protein family HMM PF00005. | Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] | 0.683 |
ABK71692.1 | wecA | MSMEG_6366 | MSMEG_4947 | O-antigen export system, ATP-binding protein; Identified by match to protein family HMM PF00005. | Glycosyl trasferase; Involved in the biosynthesis of the disaccharide D-N- acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial cell wall as a linker connecting arabinogalactan and peptidoglycan via a phosphodiester linkage. Catalyzes the transfer of the N-acetylglucosamine-1-phosphate (GlcNAc-1P) moiety from UDP-GlcNAc onto the carrier lipid decaprenyl phosphate (C50-P), yielding GlcNAc- pyrophosphoryl-decaprenyl (GlcNAc-PP-C50). | 0.575 |
ABK72696.1 | ABK74693.1 | MSMEG_1684 | MSMEG_1929 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.776 |
ABK72696.1 | ABK76192.1 | MSMEG_1684 | MSMEG_6369 | Conserved hypothetical protein. | O-antigen export system, permease protein; Identified by match to protein family HMM PF01061. | 0.658 |
ABK72696.1 | aftA | MSMEG_1684 | MSMEG_6386 | Conserved hypothetical protein. | Membrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. | 0.439 |
ABK72696.1 | glfT1 | MSMEG_1684 | MSMEG_6367 | Conserved hypothetical protein. | Glycosyl transferase, group 2 family protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the transfer of the first two galactofuranosyl (Galf) units from UDP- galactofuranose (UDP-Galf) onto the rhamnosyl-GlcNAc-diphospho- decaprenol (Rha-GlcNAc-PP-C50) acceptor, yielding galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50). Thus, GlfT1 is the initiator of galactan synthesis, while GlfT2 cont [...] | 0.764 |
ABK72696.1 | glfT2 | MSMEG_1684 | MSMEG_6403 | Conserved hypothetical protein. | Bifunctional udp-galactofuranosyl transferase glft; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofu [...] | 0.438 |
ABK74693.1 | ABK72696.1 | MSMEG_1929 | MSMEG_1684 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.776 |
ABK74693.1 | ABK76192.1 | MSMEG_1929 | MSMEG_6369 | Conserved hypothetical protein. | O-antigen export system, permease protein; Identified by match to protein family HMM PF01061. | 0.592 |
ABK74693.1 | aftA | MSMEG_1929 | MSMEG_6386 | Conserved hypothetical protein. | Membrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. | 0.441 |
ABK74693.1 | glfT1 | MSMEG_1929 | MSMEG_6367 | Conserved hypothetical protein. | Glycosyl transferase, group 2 family protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the transfer of the first two galactofuranosyl (Galf) units from UDP- galactofuranose (UDP-Galf) onto the rhamnosyl-GlcNAc-diphospho- decaprenol (Rha-GlcNAc-PP-C50) acceptor, yielding galactofuranosyl- galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha- GlcNAc-PP-C50). Thus, GlfT1 is the initiator of galactan synthesis, while GlfT2 cont [...] | 0.734 |
ABK76192.1 | ABK71692.1 | MSMEG_6369 | MSMEG_6366 | O-antigen export system, permease protein; Identified by match to protein family HMM PF01061. | O-antigen export system, ATP-binding protein; Identified by match to protein family HMM PF00005. | 0.999 |
ABK76192.1 | ABK72696.1 | MSMEG_6369 | MSMEG_1684 | O-antigen export system, permease protein; Identified by match to protein family HMM PF01061. | Conserved hypothetical protein. | 0.658 |
ABK76192.1 | ABK74693.1 | MSMEG_6369 | MSMEG_1929 | O-antigen export system, permease protein; Identified by match to protein family HMM PF01061. | Conserved hypothetical protein. | 0.592 |
ABK76192.1 | bpa | MSMEG_6369 | MSMEG_6365 | O-antigen export system, permease protein; Identified by match to protein family HMM PF01061. | Conserved hypothetical protein; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction (By similarity); Belongs to the Bpa family. | 0.961 |
ABK76192.1 | glf | MSMEG_6369 | MSMEG_6404 | O-antigen export system, permease protein; Identified by match to protein family HMM PF01061. | UDP-galactopyranose mutase; Identified by match to protein family HMM PF03275; match to protein family HMM TIGR00031. | 0.797 |