STRINGSTRING
ABK74530.1 ABK74530.1 dprE2 dprE2 ABK72375.1 ABK72375.1 dprE1 dprE1 ABK71134.1 ABK71134.1 ABK72840.1 ABK72840.1 ABK74962.1 ABK74962.1 ABK74014.1 ABK74014.1 aftA aftA ABK74230.1 ABK74230.1 aftC aftC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
ABK74530.1Identified by match to protein family HMM PF04138. (135 aa)    
Predicted Functional Partners:
dprE2
Putative oxidoreductase in MprA 5'region; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'su [...]
 
  
 0.897
ABK72375.1
Probable arabinosyltransferase A; Identified by match to protein family HMM PF04602.
 
  
 0.895
dprE1
Oxidoreductase, FAD-binding; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans. DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate chann [...]
 
  
 0.891
ABK71134.1
Probable arabinosyltransferase B; Identified by match to protein family HMM PF04602.
 
  
 0.806
ABK72840.1
Probable arabinosyltransferase A; Identified by match to protein family HMM PF04602.
 
  
 0.799
ABK74962.1
Prenyltransferase, UbiA family protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Catalyzes the transfer of a 5-phosphoribosyl residue from phosphoribose diphosphate (pRpp) to decaprenyl phosphate (DP) to form decaprenylphosphoryl-5-phosphoribose (DPPR).
 
  
 0.770
ABK74014.1
Short chain dehydrogenase; Identified by match to protein family HMM PF00106.
 
    0.739
aftA
Membrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf.
 
  
 0.732
ABK74230.1
GntR-family protein regulator; Identified by match to protein family HMM PF00155; match to protein family HMM PF00392.
       0.728
aftC
Putative conserved integral membrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.
 
  
 0.684
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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