node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK69767.1 | ABK72465.1 | MSMEG_5265 | MSMEG_6649 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Conserved hypothetical protein. | 0.581 |
ABK69767.1 | ABK73212.1 | MSMEG_5265 | MSMEG_2394 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | 0.921 |
ABK69767.1 | ABK73488.1 | MSMEG_5265 | MSMEG_6664 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Methylenetetrahydrofolate reductase family protein, putative; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.713 |
ABK69767.1 | ABK74802.1 | MSMEG_5265 | MSMEG_2359 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Methionine synthase, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | 0.507 |
ABK69767.1 | ABK75362.1 | MSMEG_5265 | MSMEG_4957 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.937 |
ABK69767.1 | metE | MSMEG_5265 | MSMEG_6638 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.970 |
ABK69767.1 | metH | MSMEG_5265 | MSMEG_4185 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.975 |
ABK69767.1 | metK | MSMEG_5265 | MSMEG_3055 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.640 |
ABK69767.1 | metZ | MSMEG_5265 | MSMEG_0769 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.919 |
ABK72465.1 | ABK69767.1 | MSMEG_6649 | MSMEG_5265 | Conserved hypothetical protein. | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | 0.581 |
ABK72465.1 | ABK73212.1 | MSMEG_6649 | MSMEG_2394 | Conserved hypothetical protein. | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | 0.575 |
ABK72465.1 | ABK73488.1 | MSMEG_6649 | MSMEG_6664 | Conserved hypothetical protein. | Methylenetetrahydrofolate reductase family protein, putative; Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.781 |
ABK72465.1 | ABK74802.1 | MSMEG_6649 | MSMEG_2359 | Conserved hypothetical protein. | Methionine synthase, vitamin-B12 independent; Identified by match to protein family HMM PF01717. | 0.688 |
ABK72465.1 | ABK75362.1 | MSMEG_6649 | MSMEG_4957 | Conserved hypothetical protein. | Homoserine dehydrogenase; Identified by match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.510 |
ABK72465.1 | glyA | MSMEG_6649 | MSMEG_5249 | Conserved hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.574 |
ABK72465.1 | metE | MSMEG_6649 | MSMEG_6638 | Conserved hypothetical protein. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.686 |
ABK72465.1 | metH | MSMEG_6649 | MSMEG_4185 | Conserved hypothetical protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.943 |
ABK72465.1 | metK | MSMEG_6649 | MSMEG_3055 | Conserved hypothetical protein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.615 |
ABK72465.1 | metZ | MSMEG_6649 | MSMEG_0769 | Conserved hypothetical protein. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.581 |
ABK73212.1 | ABK69767.1 | MSMEG_2394 | MSMEG_5265 | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01053. | Putative cystathionine gamma-synthase; Identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212. | 0.921 |