node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38066.1 | mfd | MexAM1_META1p0099 | MexAM1_META1p4552 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.741 |
ACS38066.1 | mfd-2 | MexAM1_META1p0099 | MexAM1_META1p1061 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DEAD/DEAH box helicase domain protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.741 |
ACS38066.1 | polA | MexAM1_META1p0099 | MexAM1_META1p2436 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.565 |
ACS38066.1 | recA | MexAM1_META1p0099 | MexAM1_META1p2721 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.603 |
ACS38066.1 | rho | MexAM1_META1p0099 | MexAM1_META1p1454 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.511 |
ACS38066.1 | topA | MexAM1_META1p0099 | MexAM1_META1p3523 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.555 |
ACS38066.1 | uvrA | MexAM1_META1p0099 | MexAM1_META1p4267 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DNA excision repair enzyme subunit, with UvrBC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.913 |
ACS38066.1 | uvrB | MexAM1_META1p0099 | MexAM1_META1p4445 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | UvrABC system protein B (UvrB protein) (Excinuclease ABC subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesi [...] | 0.988 |
ACS38066.1 | uvrC | MexAM1_META1p0099 | MexAM1_META1p3083 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DNA exisiton repair enzyme together with UvrAB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.791 |
ACS38066.1 | uvrD | MexAM1_META1p0099 | MexAM1_META1p0214 | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | DNA-dependent ATPase I and helicase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.543 |
mfd | ACS38066.1 | MexAM1_META1p4552 | MexAM1_META1p0099 | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | 0.741 |
mfd | mfd-2 | MexAM1_META1p4552 | MexAM1_META1p1061 | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DEAD/DEAH box helicase domain protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.913 |
mfd | polA | MexAM1_META1p4552 | MexAM1_META1p2436 | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.555 |
mfd | topA | MexAM1_META1p4552 | MexAM1_META1p3523 | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.532 |
mfd | uvrA | MexAM1_META1p4552 | MexAM1_META1p4267 | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA excision repair enzyme subunit, with UvrBC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.741 |
mfd | uvrB | MexAM1_META1p4552 | MexAM1_META1p4445 | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | UvrABC system protein B (UvrB protein) (Excinuclease ABC subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesi [...] | 0.407 |
mfd | uvrD | MexAM1_META1p4552 | MexAM1_META1p0214 | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA-dependent ATPase I and helicase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.523 |
mfd-2 | ACS38066.1 | MexAM1_META1p1061 | MexAM1_META1p0099 | DEAD/DEAH box helicase domain protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Excinuclease ABC, A subunit; Function of strongly homologous gene; enzyme. | 0.741 |
mfd-2 | mfd | MexAM1_META1p1061 | MexAM1_META1p4552 | DEAD/DEAH box helicase domain protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | Transcription repair coupling protein, ATP-dependent helicase; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.913 |
mfd-2 | polA | MexAM1_META1p1061 | MexAM1_META1p2436 | DEAD/DEAH box helicase domain protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.658 |