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ilvC ilvC ilvH ilvH ilvD-2 ilvD-2 ilvI ilvI ilvD ilvD ACS42655.1 ACS42655.1 leuC leuC ACS40273.1 ACS40273.1 leuD leuD leuB leuB leuA leuA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase III, small subunit; Function of strongly homologous gene; enzyme.
 
 
 0.997
ilvD-2
Putative dihydroxyacid dehydratase (ilvD-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the IlvD/Edd family.
 
 
 0.995
ilvI
Acetolactate synthase III, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 
 0.994
ilvD
Dihydroxyacid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family.
 
 
 0.992
ACS42655.1
Putative acetolactate synthase large subunit (ilvG); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the TPP enzyme family.
 
 
 0.985
leuC
3-isopropylmalate isomerase, subunit with LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
 0.977
ACS40273.1
Putative decarboxylase, Thiamine pyrophosphate-requiring; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the TPP enzyme family.
 
 
 0.946
leuD
Isopropylmalate dehydratase small subunit/isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
  
 0.936
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
  
 0.933
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
  
 0.919
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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