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ccr ccr croR croR epi epi ecm ecm meaC meaC ibd2 ibd2 ACS41931.1 ACS41931.1 hbdA hbdA acs acs ACS42261.1 ACS42261.1 ACS42488.1 ACS42488.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ccrcrotonyl-CoA carboxylase/reductase; Function experimentally demonstrated in the studied strain; enzyme. (432 aa)    
Predicted Functional Partners:
croR
Crotonase; Involved in the regeneration of glyoxylate from a molecule of acetyl-CoA.
 
 0.977
epi
ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.966
ecm
ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate.
   
 0.957
meaC
Mesaconyl-CoA hydratase; Part of the glyoxylate regeneration cycle that is essential for growth on C1 and C2 compounds; Function experimentally demonstrated in the studied strain; enzyme.
 
 
 0.885
ibd2
isobutyryl-CoA dehydrogenase; Function experimentally demonstrated in the studied strain; enzyme.
  
 
 0.812
ACS41931.1
Putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the HpcH/HpaI aldolase family.
 
  
 0.761
hbdA
3-hydroxybutyryl-CoA dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
  
  
 0.697
acs
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
 
 
  
 0.697
ACS42261.1
Putative enoyl-CoA hydratase/isomerase family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
  
 
 0.695
ACS42488.1
enoyl-CoA hydratase; Function of strongly homologous gene; enzyme.
  
 
 0.695
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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