node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS38149.1 | meaB | MexAM1_META1p0187 | MexAM1_META1p0188 | Putative pyrrolidone-carboxylate peptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the peptidase C15 family. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.800 |
ACS38746.1 | meaB | MexAM1_META1p0825 | MexAM1_META1p0188 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.772 |
ecm | epi | MexAM1_META1p0180 | MexAM1_META1p0839 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.995 |
ecm | mcmA | MexAM1_META1p0180 | MexAM1_META1p5251 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.978 |
ecm | mcmB | MexAM1_META1p0180 | MexAM1_META1p2390 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | methylmalonyl-CoA beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.982 |
ecm | meaB | MexAM1_META1p0180 | MexAM1_META1p0188 | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.997 |
epi | ecm | MexAM1_META1p0839 | MexAM1_META1p0180 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | 0.995 |
epi | matB | MexAM1_META1p0839 | MexAM1_META1p0644 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.901 |
epi | mcmA | MexAM1_META1p0839 | MexAM1_META1p5251 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.987 |
epi | mcmB | MexAM1_META1p0839 | MexAM1_META1p2390 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.976 |
epi | meaB | MexAM1_META1p0839 | MexAM1_META1p0188 | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.935 |
matB | epi | MexAM1_META1p0644 | MexAM1_META1p0839 | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.901 |
matB | mcmA | MexAM1_META1p0644 | MexAM1_META1p5251 | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.945 |
matB | mcmB | MexAM1_META1p0644 | MexAM1_META1p2390 | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.942 |
matB | meaB | MexAM1_META1p0644 | MexAM1_META1p0188 | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.673 |
mcmA | ecm | MexAM1_META1p5251 | MexAM1_META1p0180 | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for M.extorquens growth on one- and two-carbon compounds such as ethylamine, methanol or ethanol as sole carbon source. This enzyme acts as a regulatory metabolic control point in this pathway, that allows M.extorquens to efficiently restore metabolic balance when challenged with a sudden change in the growth substrate. | 0.978 |
mcmA | epi | MexAM1_META1p5251 | MexAM1_META1p0839 | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.987 |
mcmA | matB | MexAM1_META1p5251 | MexAM1_META1p0644 | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Malonyl CoA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.945 |
mcmA | mcmB | MexAM1_META1p5251 | MexAM1_META1p2390 | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.988 |
mcmA | meaB | MexAM1_META1p5251 | MexAM1_META1p0188 | methylmalonyl-CoA mutase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | methylmalonyl-CoA mutase accessory protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.999 |